{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T17:21:29Z","timestamp":1698254489264},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":7901,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C57BL\/6 (C57BL) and SWV mice were treated subcutaneously with triamcinolone acetonide in a single dose of 1.0\u20137.0 mg\/kg on day 12 of pregnancy, and the palate of their fetuses was examined at term. In C57BL mice palatal slit occurred spontaneously and its frequency increased with increasing doses of triamcinolone. However, this defect was not seen in SWV fetuses, even when dams were treated with the doses that induced cleft palate. The frequency of cleft palate increased in both C57BL and SWV as the dose of triamcinolone increased. Fetal mortality increased in SWV, but not in C57BL, with increasing doses of triamcinolone. Dose\u2010response relations were analyzed by the log\u2010probit transformation method. In C57BL mice, the slope of the doseresponse curve of palatal slit was significantly different from that of cleft palate. In contrast, the dose\u2010response curves of cleft palate were similar in both C57BL and SWV; the median effective dose was significantly greater in C57BL than in SWV. The mechanism of induced palatal slit appears to be different from that of induced cleft palate; the mechanism of cleft palate induction may be the same in both C57BL and SWV. The slope of the dose\u2010response curve of fetal mortality in SWV mice was different from that of cleft palate; the mechanisms underlying the resorption and cleft palate responses must be different.<\/jats:p>","DOI":"10.1002\/tera.1420280203","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:45:23Z","timestamp":1118501123000},"page":"165-168","source":"Crossref","is-referenced-by-count":17,"title":["Dose\u2010response relations of palatal slit, cleft palate, and fetal mortality in mice treated with a glucocorticoid"],"prefix":"10.1002","volume":"28","author":[{"given":"Takao","family":"Kusanagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160309"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180210"},{"key":"e_1_2_1_4_1","first-page":"55","volume-title":"Developmental Toxicology","author":"Biddle F. G.","year":"1981"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/genetics\/84.4.743","article-title":"Genetics of cortisone\u2010induced cleft palate in the mouse\u2013Embryonic and maternal effects","volume":"84","author":"Biddle F. G.","year":"1976","journal-title":"Genetics"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420220115"},{"key":"e_1_2_1_7_1","first-page":"88","article-title":"Morphogenesis of cleft palate induced by exogenous factors. I. The sensitivity period after the administration of cortisone","volume":"19","author":"Dost\u00e1l M.","year":"1971","journal-title":"Folia Morphol."},{"key":"e_1_2_1_8_1","volume-title":"Statistical Method in Biological Assay","author":"Finney D. J.","year":"1978"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420210106"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420240109"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","unstructured":"Kusanagi T.(1983a) Palatal slit: A new spontaneous defect of the palate of C57BL\/6 mice.Teratology(in press).","DOI":"10.1002\/tera.1420280118"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","unstructured":"Kusanagi T.(1983b) Occurrence of cleft palate. Palatal slit and fetal death in mice with a glucocorticoid: A embryo transfer experiment.Teratology(in press).","DOI":"10.1002\/tera.1420270313"},{"key":"e_1_2_1_13_1","volume-title":"Bioassay\u2013Design and Analysis","author":"Sakuma A.","year":"1964"},{"key":"e_1_2_1_14_1","first-page":"213","article-title":"The teratogenic effects of hydrocortisone on palatal development in the hamster","volume":"35","author":"Shah R. M.","year":"1976","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_15_1","first-page":"262","volume-title":"Teratology: Principles and Techniques","author":"Wilson J. G.","year":"1965"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420280203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420280203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T08:43:19Z","timestamp":1697791399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420280203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,10]]}},"alternative-id":["10.1002\/tera.1420280203"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420280203","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}