{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T20:20:38Z","timestamp":1697919638102},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,19]],"date-time":"2005-05-19T00:00:00Z","timestamp":1116460800000},"content-version":"vor","delay-in-days":7901,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fetal exposure to excess vitamin A results in a highly variable degree of lung pathology and high neonatal mortality in the Long\u2013Evans rat. The present study evaluated O<jats:sub>2<\/jats:sub> consumption in newborn of vitamin A\u2010treated, vehicle\u2010treated, and untreated pregnancies on five consecutive postnatal days beginning with the day of delivery (D0). Pregnant female rats were treated by gavage with 160,000 USP units of retinyl acetate dissolved in 0.5 ml corn oil on days 15 through 19 of gestation. Vehicle and undisturbed controls were run concurrently. All animals delivered spontaneously, and the pups were tattooed and individually tested in a closed system consisting of three chambers submerged within a thermostatically controlled water bath at 33\u00b0C.<\/jats:p><jats:p>Vitamin A\u2010exposed pups, as a group, have significantly lower QO<jats:sub>2<\/jats:sub> (ml O<jats:sub>2<\/jats:sub> consumed\/min\/kg body weight) values than controls through postnatal day 2 (p &lt; 0.05). By days 3 and 4 of age, the mean QO<jats:sub>2<\/jats:sub> values of surviving vitamin A\u2010treated pups were similar to those of controls. A QO<jats:sub>2<\/jats:sub> of 30 or greater on day 0 appears to be critical for early neonatal survival of vitamin A\u2010exposed pups, as 87% of the pups with initial QO<jats:sub>2<\/jats:sub> &lt; 30 died prior to day 4. Oxygen consumption rates in teratogen\u2010exposed pups exhibiting low QO<jats:sub>2<\/jats:sub> on day 0 rarely reached normal levels. In contrast, the occasional control pup with such low initial levels were well within normal limits (X\u0304 \u00b1 1 SD) by the following day.<\/jats:p><jats:p>These studies demonstrate a marked effect of prenatal insult on respiratory function and strongly suggest that the nonivasive determination of QO<jats:sub>2<\/jats:sub>, 2\u20136 hours after birth provides a means to identify both moderately and severely affected individuals thereby permitting sequential study of their ensuing development of atelectasis neonatorum and apparent hyalin membrane disease.<\/jats:p>","DOI":"10.1002\/tera.1420280211","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:45:23Z","timestamp":1118501123000},"page":"219-227","source":"Crossref","is-referenced-by-count":8,"title":["Oxygen consumption and survival prediction in neonatal rats exposed to prenatal hypervitaminosis A"],"prefix":"10.1002","volume":"28","author":[{"given":"L. M.","family":"Newman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S. A.","family":"Cadogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,19]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"70","article-title":"Prematurity in the rat. III. Effect of oxygen supply","volume":"39","author":"Cueza J. M.","year":"1981","journal-title":"Biol. Neonate"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230210"},{"key":"e_1_2_1_4_1","first-page":"58A","article-title":"Characterization of morphological and physiological abnormalities following fetal hypervitaminosis A exposure in the rat","volume":"21","author":"Newman L. M.","year":"1980","journal-title":"Teratology"},{"key":"e_1_2_1_5_1","series-title":"Teratogenesis and Reproductive Toxicology","first-page":"237","author":"Newman L. M.","year":"1983"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092040209"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270315"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1960.sp006547"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1960.sp006570"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000240971"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420280211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420280211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T08:42:03Z","timestamp":1697791323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420280211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,10]]}},"alternative-id":["10.1002\/tera.1420280211"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420280211","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}