{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:07:46Z","timestamp":1760548066976},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":7790,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1984,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three tetrachlorobenzene (TCB) congeners (1,2,3,4\u2010, 1,2,3,5\u2010, and 1,2,4,5\u2010) were administered daily by gavage to pregnant Sprague\u2010Dawley rats at levels of 50, 100, or 200 mg\/kg from day 6 through day 15 of gestation. Mothers were sacrificed on day 21 of gestation and the pups removed by cesarian section for teratological evaluation. Administration of 1,2,3,4\u2010 and 1,2,3,5\u2010TCB failed to alter maternal body weight, organ weights, hematological, or the biochemical parameters studied. The highest dose level of 1,2,4,5\u2010tetrachlorobenzene caused maternal death in nine of ten animals. In addition it induced mixed function oxidases and increased serum cholesterol values at 50 and 100 mg\/kg. There was a decrease in the number of fetuses at the highest dose levels of 1,2,3,4\u2010 and 1,2,3,5\u2010TCB and at the lowest dose level of the 1,2,4,5\u2010 congener. None of the congeners produced any anomalies. There were no treatment\u2010related histopathological changes in either the mothers or fetuses. Residues of all three congeners were found in maternal and fetal tissues but generally the amounts of the 1,2,4,5\u2010 isomer were about 100 times higher than the other two.<\/jats:p>","DOI":"10.1002\/tera.1420290104","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:48:43Z","timestamp":1118501323000},"page":"21-27","source":"Crossref","is-referenced-by-count":8,"title":["A teratological evaluation and analysis of fetal tissue levels following administration of tetrachlorobenzene isomers to the rat"],"prefix":"10.1002","volume":"29","author":[{"given":"S.","family":"Kacew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Ruddick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Parulekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. 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