{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:52:21Z","timestamp":1698025941170},"reference-count":8,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":7730,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tridemorph (<jats:italic>N<\/jats:italic>\u2010tridecyl\u20102,6\u2010dimethylmorpholine), the active ingredient of the commercially formulated fungicide Calixin, is a teratogen in rats and mice. The no\u2010effect level for embryotoxic effects was 27.5 mg\/kg for mice and 20.6 mg\/kg for rats.<\/jats:p><jats:p>By contrast, when Calixin, which contains 83% tridemorph, was administered orally at dose levels of 0.156, 0.722, and 3.909 mg\/kg, no embryotoxic effects were observed in two strains of rats. Our extensive investigations, carried out under exposure conditions resembling as closely as possible those reported in another study, did not reproduce the previous findings of teratogenicity of Calixin.<\/jats:p>","DOI":"10.1002\/tera.1420290212","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:48:49Z","timestamp":1118501329000},"page":"259-269","source":"Crossref","is-referenced-by-count":6,"title":["An embryotoxicity study of the fungicide tridemorph and its commercial formulation Calixin"],"prefix":"10.1002","volume":"29","author":[{"given":"J.","family":"Merkle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. P.","family":"Gelbke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520292609115636"},{"key":"e_1_2_1_3_1","unstructured":"Federal Register 1978 43 163 Environmental Protection Agency Pesticide Programs. Proposed Guidelines for Registering Pesticides in the US.; Hazard Evaluation: Humans and Domestic Animals"},{"key":"e_1_2_1_4_1","volume-title":"Verteilungsfreie Methoden in der Biostatistik","author":"Fisher","year":"1973"},{"key":"e_1_2_1_5_1","volume-title":"Angewandte mathematische Statistik","author":"Mann\u2010Whitney","year":"1970"},{"key":"e_1_2_1_6_1","first-page":"55","article-title":"The teratogenic effect of the fungicide Calixin","volume":"6","author":"Schtenberg A. J.","year":"1981","journal-title":"Voprosi Pitanija"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/2528930"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.2307\/2556164"},{"key":"e_1_2_1_9_1","volume-title":"Teratology: Principles and Techniques","author":"Wilson J. S.","year":"1965"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420290212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420290212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:46:59Z","timestamp":1697795219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420290212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,4]]}},"alternative-id":["10.1002\/tera.1420290212"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420290212","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4]]}}}