{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:51:40Z","timestamp":1700412700727},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":7730,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1984,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C57BL\/6 mice were treated subcutaneously with triamcinolone acetonide in a single dose of 2.5\u201315.0 mg\/kg once on days 6\u201315 of pregnancy (vaginal plug = day 0) and the palate of their fetuses was examined at term. The sensitive stages of palatal slit and cleft palate induction were studied and dose\u2010response relations on days 9 and 12 of pregnancy were analyzed by the log\u2010probit transformation method and compared. The test of significant increase in the frequencies of palatal slit and cleft palate showed that the sensitive period of palatal slit began earlier and ended later than that of cleft palate. On day 9 of pregnancy, the slope of the palatal slit response was similar to that of the cleft palate response, but the median effective dose of the former was lower than that of the latter. The slope of the palatal slit response was similar on days 9 and 12; however, the median effective dose was significantly greater on day 9. By contrast, the slope of the cleft palate response on day 12 was significantly different from that on day 9. The results of these doseresponse analyses suggest that the underlying mechanism may be the same in palatal slit induction on days 9 and 12 and in cleft palate induction on day 9; the mechanism underlying the cleft palate response on day 12 is different from that of the other three responses, and there is more than one mechanism for cleft palate induced by triamcinolone.<\/jats:p>","DOI":"10.1002\/tera.1420290214","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:48:49Z","timestamp":1118501329000},"page":"281-286","source":"Crossref","is-referenced-by-count":7,"title":["Sensitive stages and dose\u2010response analyses of palatal slit and cleft palate in C57BL\/6 mice treated with a glucocorticoid"],"prefix":"10.1002","volume":"29","author":[{"given":"Takao","family":"Kusanagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040106"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420220213"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001060202"},{"key":"e_1_2_1_5_1","volume-title":"Statistical Method in Biological Assay","author":"Finney D. J.","year":"1978"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177703569"},{"key":"e_1_2_1_7_1","first-page":"245","article-title":"Experimental studies on the cleft palate induction by glucocorticoids in mice","volume":"13","author":"Handa S.","year":"1973","journal-title":"Cong. Anom."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070310"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270313"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280118"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280203"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270313"},{"key":"e_1_2_1_13_1","first-page":"202","article-title":"Studies on mechanisms manifesting congenital anomalies","volume":"8","author":"Murakami U.","year":"1963","journal-title":"Jpn. J. Hum. Genet."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030430407"},{"key":"e_1_2_1_15_1","first-page":"213","article-title":"The teratogenic effects of hydrocortisone on palatal development in the hamster","volume":"35","author":"Shah R. M.","year":"1976","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050115"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3686.862"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420290214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420290214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:47:09Z","timestamp":1697795229000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420290214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,4]]}},"alternative-id":["10.1002\/tera.1420290214"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420290214","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4]]}}}