{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T18:32:25Z","timestamp":1751481145493},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T00:00:00Z","timestamp":1116806400000},"content-version":"vor","delay-in-days":7600,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1984,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of the present research was to determine the effect of in utero ethanol exposure on cardiac muscle development. Pregnant albino mice (Swiss strain) at 8 days of gestation were divided into three groups: a normal group fed Purina lab chow for rodents and water ad libitum; an ethanol group fed the liquid diet ENSURE with 20% of the calories derived from ethanol (12.6 \u00b1 1.2 gm\/kg body weight per day); and an isocaloric group pairfed ENSURE with 20% of the calories derived from sucrose. These diets were continued until birth, at which time the litter size, crown to rump length, and weight were recorded. Randomly selected neonatal pups from each litter were decapitated and their hearts immediately processed for transmission electron microscopy. Litter size, crown to rump length, and body weight of the ethanol\u2010treated mice at birth were significantly less than normal but not less than pairfed controls. Ultrastructural evaluation of cardiac muscle from mice treated in utero with ethanol in comparison to that from both normal and pairfed control animals revealed various degrees of morphological alterations. The most pronounced alterations were in mitochondrial structure and included an increase in the amount of inner mitochondrial membrane. Myofibrillar abnormalities were also evident in the ethanol group but not in either control group. These abnormalities included a decrease in the myofibril volume per cytoplasmic volume and a disruption in myofibril organization particularly the Zbands. The ultrastructural alterations in the cardiac muscle from the ethanol treated group were not a result of malnutrition or dehydration as the pairfed group did not exhibit these changes. It is apparent from this study that exposure of mice in utero to ethanol can cause ultrastructural abnormalities in cardiac muscle cells. Whether these changes result in heart pathophysiology and persist to adulthood are not known.<\/jats:p>","DOI":"10.1002\/tera.1420300116","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:48:59Z","timestamp":1118501339000},"page":"119-129","source":"Crossref","is-referenced-by-count":20,"title":["Cardiac muscle development in mice exposed to ethanol in utero"],"prefix":"10.1002","volume":"30","author":[{"given":"Cynthia","family":"Uphoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Nyquist\u2010Battie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Toth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90151-X"},{"key":"e_1_2_1_3_1","first-page":"1943","volume-title":"Heart Diseases: A Textbook of Cardiovascular Medicine","author":"Braunwald E.","year":"1980"},{"key":"e_1_2_1_4_1","volume-title":"Field and Laboratory Methods for General Ecology","author":"Brower T. E.","year":"1977"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150303"},{"key":"e_1_2_1_6_1","first-page":"502","volume-title":"Cell Pathology","author":"Cheville N. F.","year":"1976"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/109.6.999"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0376-8716(77)90043-6"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(76)80075-0"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480150105013"},{"key":"e_1_2_1_11_1","first-page":"530","volume-title":"Ultrastructural Pathology of the Cell","author":"Ghadially F. N.","year":"1975"},{"key":"e_1_2_1_12_1","first-page":"15","article-title":"The effect of maternal alcohol consumption on the viability and visceral development of the newborn rat","volume":"16","author":"Henderson G. I.","year":"1977","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"e_1_2_1_13_1","first-page":"593","article-title":"The ultrastructure of fatty liver induced by prolonged ethanol ingestion","volume":"49","author":"Iseri O. A.","year":"1966","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(73)91092-1"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"819","DOI":"10.15288\/qjsa.1968.29.819","article-title":"Effect of ethanol on rat liver V. Morphological and functional changes after prolonged consumption of various alcoholic beverages","volume":"29","author":"Kiessling K. H.","year":"1968","journal-title":"Quant. J. Stud. Alcohol."},{"key":"e_1_2_1_16_1","first-page":"339","article-title":"Ethanol and the human liver. Structural and metabolic changes in liver mitochondria","volume":"4","author":"Kiessling K. H.","year":"1971","journal-title":"Cytobiologie"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.51.595.325"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90785-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(82)90581-1"},{"key":"e_1_2_1_20_1","first-page":"270","volume-title":"Medical Primatology","author":"Leiber C. S.","year":"1972"},{"key":"e_1_2_1_21_1","volume-title":"Atlas of the Ultrastructure of Diseased Human Muscle","author":"Maire G. P.","year":"1972"},{"key":"e_1_2_1_22_1","first-page":"2207","article-title":"Unterzuchunger zur Alkohol\u2010Embry\u2010opathie","volume":"96","author":"Majewski F.","year":"1978","journal-title":"Fortschritte der Med."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(78)90080-1"},{"key":"e_1_2_1_24_1","first-page":"748","article-title":"The hepatic lesions produced in the rat by chronic alcoholic intoxication","volume":"15","author":"Oudea M. C.","year":"1970","journal-title":"Rev. Eur. Clin. Biol."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(64)90107-7"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1977.tb05876.x"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190305"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1975.tb19165.x"},{"key":"e_1_2_1_29_1","first-page":"28","article-title":"Alcoholic myopathy in heart and skeletal muscle","volume":"28","author":"Rubin E.","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"e_1_2_1_30_1","first-page":"620","article-title":"Effects of ethanol on the biogenesis of mitochondrial membranes and associated mitochondrial functions","volume":"23","author":"Rubin E.","year":"1970","journal-title":"Lab. Invest."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/13.3.136"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(79)90290-4"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6992275"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6795717"},{"key":"e_1_2_1_35_1","first-page":"645","article-title":"Chronic alcoholism with fatty metamorphosis of the liver: Mitochondrial alterations in hepatic cells","volume":"44","author":"Svoboda D. T.","year":"1964","journal-title":"Amer. J. Pathol."},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(77)90328-8"},{"key":"e_1_2_1_37_1","volume-title":"Stereological methods IV. Practical methods for biological morphometry","author":"Weibel E. R.","year":"1979"},{"key":"e_1_2_1_38_1","first-page":"572","article-title":"Interaction of ethanol and nutrition during gestation: Influence on maternal and offspring development in the rat","volume":"216","author":"Weiner S. G.","year":"1981","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420300116","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420300116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:46:32Z","timestamp":1697751992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420300116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,8]]}},"alternative-id":["10.1002\/tera.1420300116"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420300116","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,8]]}}}