{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T08:17:05Z","timestamp":1698049025730},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T00:00:00Z","timestamp":1116806400000},"content-version":"vor","delay-in-days":7600,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1984,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A refined technique of amniotic sac puncturing at day 16.2 (i.e., 16 + 2\/10 days) of gestation was employed in order to produce a series of total clefts and rare forms of partial clefts in Sprague\u2010Dawley rat fetuses. From a total of 410 fetuses of a precise, individually determined age, 95 upper jaws were examined in the scanning electron microscope and, in part, in serial Epon sections. All fetal heads were examined macroscopically. Total clefts were found in 48.9% of a total of 184 viable rat fetuses examined at day 17.8 of smear age and in 21.8% of a total of 211 fetuses examined at day 19.3. Partial clefts were observed in 14.1% and 18.5% of fetuses at days 17.8 and 19.3 of smear age, respectively. At day 19.3, 16.1% of the viable fetuses showed a very inconspicuous, small abnormality (with residual clefting and incomplete fusion with the nasal septum) in the region of the palatine foraminae. Morphological observations suggested that under conditions of detained palatal closure (1) fusion of the soft palatal shelves commences independently from and prior to fusion of the hard palate, (2) delayed palatal shelf fusion proceeding in the anterior direction may occur with or without remaining sickle\u2010shaped clefts in the anterior hard palate, and (3) in fetuses with small sickle\u2010shaped clefts, fusion of the palatal shelves with the nasal septum does not occur. The present data imply that an almost total prenatal repair and delayed closure of the secondary palate may occur in rats that, at day 16.2 of multiple analysis age, most certainly had a total palatal cleft resulting from tongue resistance.<\/jats:p>","DOI":"10.1002\/tera.1420300117","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:48:59Z","timestamp":1118501339000},"page":"131-142","source":"Crossref","is-referenced-by-count":5,"title":["Prenatal repair of experimentally induced clefts in the secondary palate of the rat"],"prefix":"10.1002","volume":"30","author":[{"given":"Peter M.","family":"Schuepbach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert E.","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/0950-7671\/28\/3\/301"},{"key":"e_1_2_1_3_1","first-page":"41","article-title":"Distribution of midpalatine cysts: A reevaluation of human palatal closure mechanisms","volume":"26","author":"Burdi A. R.","year":"1968","journal-title":"J. Oral Surg."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091560106"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091510202"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020105"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140305"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190212"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040109"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197107000-00009"},{"key":"e_1_2_1_11_1","first-page":"555","article-title":"Palatal shelf elevation in the wistar rat fetus","volume":"125","author":"Ferguson M. W. J.","year":"1978","journal-title":"J. Anat."},{"key":"e_1_2_1_12_1","first-page":"737","article-title":"In vitro fusion of cleft palate shelves","volume":"7","author":"Goss A. N.","year":"1970","journal-title":"Cleft palate J."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02135278"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","DOI":"10.1097\/00000441-196610000-00030","volume-title":"Atlas of Developmental Anatomy of the Face","author":"Kraus S. B.","year":"1966"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280118"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270313"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-196638060-00010"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02120118"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001640104"},{"key":"e_1_2_1_20_1","first-page":"204","article-title":"Cleft of the hard palate with soft palate integrity","volume":"18","author":"Mitts T. F.","year":"1981","journal-title":"Cleft Palate J."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(76)90140-8"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230114"},{"key":"e_1_2_1_23_1","volume-title":"Atlas der Entwicklung der Nase und des Gaumens beim Menschen","author":"Peter K.","year":"1913"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345660450032301"},{"key":"e_1_2_1_25_1","first-page":"61","article-title":"The aetiology and surgery of cleft palate with micrognathia","volume":"43","author":"Poswillo D.","year":"1968","journal-title":"Ann. R. Coll. Surg."},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367768781082915"},{"key":"e_1_2_1_27_1","first-page":"171","article-title":"Onset of the acquired potentiality for fusion in the palatal shelves of rats","volume":"16","author":"Pourtois M.","year":"1966","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_28_1","first-page":"1","article-title":"La fusion des cr\u011bte palatines et son alteration par quelques agents teratogens","volume":"79","author":"Pourtois M.","year":"1968","journal-title":"Archs Biol."},{"key":"e_1_2_1_29_1","first-page":"111","article-title":"An established routine method for differential staining of epoxy\u2010embedded tissue sections","volume":"83","author":"Schroeder H. E.","year":"1980","journal-title":"Microsc. Acta"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(83)90296-7"},{"key":"e_1_2_1_31_1","first-page":"227","article-title":"Cell release from the palatal shelves and the fusion line","volume":"11","author":"Sch\u00fcpbach P. M.","year":"1983","journal-title":"J. Biol. Bucc."},{"key":"e_1_2_1_32_1","first-page":"159","article-title":"Development of the secondary palate in the rat: A scanning electron microscopic study","volume":"3","author":"Sch\u00fcpbach P. M.","year":"1983","journal-title":"J. Craniofac. Gen. Dev. Biol."},{"key":"e_1_2_1_33_1","unstructured":"Sch\u00fcpbach P. M. A. G.D\u00f6rig\u2010Schwarzenbach andH. E.Schroeder(1984) Rare total and partial palatal clefts experimentally induced in the rat.Cleft Palate J.(in press)."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070211"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345690480050801"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.124.3219.439"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8933-4_11"},{"key":"e_1_2_1_38_1","volume-title":"Division palatine","author":"Veau V.","year":"1931"},{"key":"e_1_2_1_39_1","first-page":"176","article-title":"Closure of the secondary palate in three strains of mice","volume":"4","author":"Walker B. E.","year":"1956","journal-title":"J. Embryol. Exp. 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