{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:10:35Z","timestamp":1757542235004},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T00:00:00Z","timestamp":1116806400000},"content-version":"vor","delay-in-days":7539,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1984,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebral dysraphia was studied histologically and by graphic reconstruction in a twin at stage 13, and comparisons were made with the normal (discordant) twin. The normal, bidirectional closure of the rostral neuropore was investigated in several embryos, from which it was concluded that the situs neuroporicus is represented by the future commissural plate rather than by the (adult) lamina terminalis. In the abnormal twin the neural tube was open over part of the midbrain and forebrain, although the situs neuroporicus was closed. The experimental production of anencephaly by Giroud and co\u2010workers was reviewed, and comparisons between embryonic staging systems in the rat, mouse, and human were made. Three corresponding phases are found in the human: (1) cerebral dysraphia, occurring before or during Carnegie stage 11 (approximately 23\u201325 days); (2) exposure of a highly developing and well\u2010differentiated brain during the remainder of the embryonic period; and (3) degeneration of the exposed brain throughout the fetal period, resulting in anencephaly. Hence the abnormal twin described here is believed to represent a precursor of typical anencephaly, and is the earliest example of purely cerebral dysraphia so far recorded.<\/jats:p>","DOI":"10.1002\/tera.1420300203","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:51:25Z","timestamp":1118501485000},"page":"167-177","source":"Crossref","is-referenced-by-count":39,"title":["Cerebral dysraphia (future anencephaly) in a human twin embryo at stage 13"],"prefix":"10.1002","volume":"30","author":[{"given":"Fabiola","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan","family":"O'Rahilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"207","volume-title":"Malformations Cong\u00e9nitales du Cerveau","author":"Thomas Andr\u00e9","year":"1959"},{"key":"e_1_2_1_3_1","first-page":"219","article-title":"\u00c9tude des commissures t\u00e9lenc\u00e9phaliques chez le foetus de Rat anenc\u00e9phale","volume":"48","author":"Auroux M.","year":"1965","journal-title":"Arch. Anat. Histol. Embryol."},{"key":"e_1_2_1_4_1","first-page":"55","article-title":"The formation of neural crest from the primary optic vesicle in man","volume":"35","author":"Bartelmez G. W.","year":"1954","journal-title":"Contrib. Embryol. Carnegie Inst."},{"key":"e_1_2_1_5_1","first-page":"13","article-title":"The early development of the human brain","volume":"37","author":"Bartelmez G. W.","year":"1962","journal-title":"Contrib. Embryol. Carnegie Inst."},{"key":"e_1_2_1_6_1","first-page":"437","article-title":"Contribution \u00e0 l'\u00e9tiologie de l' anenc\u00e9phalie par l'\u00e9tude des jumeaux","volume":"98","author":"de Bellefeuille P.","year":"1969","journal-title":"Union Med. Can."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02593585"},{"key":"e_1_2_1_8_1","first-page":"200","article-title":"Diverticule t\u00e9lenc\u00e9phalique de la r\u00e9gion du neuropore ant\u00e9rieur chez un embryon humain de 35mm V. C.","volume":"50","author":"Bossy J.","year":"1966","journal-title":"C.R. Assoc. Anat."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000050404"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051140207"},{"key":"e_1_2_1_11_1","first-page":"181","article-title":"The anterior end of the neural tube and the anterior end of the body","volume":"58","author":"Dart R. A.","year":"1924","journal-title":"J. Anat."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196307000-00014"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001150104"},{"key":"e_1_2_1_14_1","first-page":"662","article-title":"Ein Fetus von 18mm Sitzh\u00f6he mit Anencephalie und Amvelie","volume":"103","author":"Dziallas P.","year":"1962","journal-title":"Morphol. Jb."},{"key":"e_1_2_1_15_1","volume-title":"The Dysraphic States from Syringomyelia to Anencephaly","author":"Gardner W. J.","year":"1973"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091890407"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315716"},{"key":"e_1_2_1_18_1","first-page":"173","volume-title":"Handbook of Clinical Neurology","author":"Giroud A.","year":"1977"},{"key":"e_1_2_1_19_1","first-page":"201","article-title":"\u00c9tude morphog\u00e9n\u00e9tique sur des embryons anenc\u00e9phales","volume":"42","author":"Giroud A.","year":"1959","journal-title":"Arch. Anat. Histol. Embryol."},{"key":"e_1_2_1_20_1","first-page":"247","article-title":"Morphogen\u00e9se de l'anenc\u00e9phalie","volume":"46","author":"Giroud A.","year":"1957","journal-title":"Arch. Anat. Microsc. Morphol. Exp."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000141703"},{"key":"e_1_2_1_22_1","first-page":"483","article-title":"Ein Fall von Anencephalie mit Rachischisis bei einem 14mm langen menschlichen Embryo, rekonstrucktiv untersucht","volume":"14","author":"Groth D.\u2010E.","year":"1928","journal-title":"Z. mikrosk. Anat. Forsch."},{"key":"e_1_2_1_23_1","first-page":"82","article-title":"Extroversion of the cerebral hemispheres in a human embryo","volume":"59","author":"Hunter R. H.","year":"1934","journal-title":"J. Anat."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.920190502"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001550403"},{"key":"e_1_2_1_26_1","first-page":"250","volume-title":"The Central Nervous System of Vertebrates","author":"Kuhlenbeck H.","year":"1973"},{"key":"e_1_2_1_27_1","volume-title":"Anencephaly","author":"Lemire R. J.","year":"1977"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000142740"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-99963-5_4"},{"key":"e_1_2_1_30_1","first-page":"15","article-title":"Neurulation: biochemical and morphological studies on primary and secondary neural tube defects","volume":"4","author":"McLone D. G.","year":"1983","journal-title":"Concepts Pediatr. Neurosurg."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280311"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304278"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(78)90201-4"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(79)90068-6"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00305401"},{"key":"e_1_2_1_36_1","first-page":"15","volume-title":"Handbook of Clinical Neurology","author":"O'Rahilly R.","year":"1977"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000145061"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00519927"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00315766"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001690302"},{"key":"e_1_2_1_41_1","unstructured":"O'Rahilly R.andF.M\u00fcller(1984b) The origin of the ectodermal ring in staged human embryos of the first five weeks.Acta anat. in press."},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091200104"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-197004000-00003"},{"key":"e_1_2_1_44_1","first-page":"1","article-title":"\u00dcber fr\u00fchembryonale Encephalomyeloschisis beim Menschen","volume":"5","author":"Politzer G.","year":"1952","journal-title":"Wien Z. Nervenheilk."},{"key":"e_1_2_1_45_1","first-page":"141","article-title":"Abnormal neural fold development in trisomy 12 and trisomy 14 mouse embryos","volume":"66","author":"Putz B.","year":"1981","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160204"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198140010-00003"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02070732"},{"key":"e_1_2_1_49_1","volume-title":"The House Mouse. Development and Normal Stages From Fertilization to 4 Weeks of Age","author":"Theiler K.","year":"1972"},{"key":"e_1_2_1_50_1","first-page":"A\u201029","article-title":"Pathogenesis of vitamin A\u2010induced exencephaly in the mouse","volume":"7","author":"Theodosis D.","year":"1973","journal-title":"Teratology"},{"key":"e_1_2_1_51_1","first-page":"189","volume-title":"Congenital Malformations, Notes and Comments","author":"Warkany J.","year":"1971"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0001566000008254"},{"key":"e_1_2_1_53_1","volume-title":"Growth Including Reproduction and Morphological Development","author":"Witschi E.","year":"1962"},{"key":"e_1_2_1_54_1","first-page":"329","article-title":"Uber die Kenntnis des abnormen Offenstehens des Neuralrohres bei menschlichen Embryonen und jungen Feten","volume":"121","author":"Wrete M.","year":"1959","journal-title":"Beitr. Pathol. Anat."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420300203","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420300203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:10:47Z","timestamp":1697749847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420300203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,10]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,10]]}},"alternative-id":["10.1002\/tera.1420300203"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420300203","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,10]]}}}