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This response was evident by a rise in the frequency of fetuses with one or more malformations (21%), and by a rise in the frequency of litters with one or more malformed fetuses (50%). Palatoschisis and greater relative intermedial canthi distance observed in this study are diagnostic features of the fetal alcohol syndrome (FAS). Although mean (\u00b1SEM) peak blood alcohol levels of 207 \u00b1 9 mg\/dl did not affect other reproductive parameters, high doses of alcohol (3.0 g\/kg) resulted in the inability of treated females to consume adequate food or water, in the complete resorption of litters, and in significant maternal mortality (88%). Fetal deaths occurred prior to gestation day 17 in the high\u2010dose alcohol group. Based on objective evaluation of differences among ethanol\u2010treated, pair\u2010fed sucrosetreated, and untreated ad libitum diet controls, the ferret would seem a valuable alternative animal species for future studies of FAS.<\/jats:p>","DOI":"10.1002\/tera.1420300208","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:51:25Z","timestamp":1118501485000},"page":"203-210","source":"Crossref","is-referenced-by-count":8,"title":["Fetal alcohol syndrome in the ferret (<i>Mustela putorius<\/i>)"],"prefix":"10.1002","volume":"30","author":[{"given":"Daniel E.","family":"McLain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne A.","family":"Roe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(79)90094-7"},{"key":"e_1_2_1_3_1","first-page":"916","article-title":"Effects of prenatal alcohol exposure on growth and development in rats","volume":"207","author":"Abel E. 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