{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:00:22Z","timestamp":1762160422144},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T00:00:00Z","timestamp":1116806400000},"content-version":"vor","delay-in-days":7539,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1984,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Newborn female BALB\/cCrgl mice received hormone treatments (daily for 5 days): 10<jats:sup>\u22121<\/jats:sup> \u03bcg diethylstilbestrol (DES), 2 \u00d7 10<jats:sup>\u22121<\/jats:sup> \u03bcg DES, 2 \u03bcg DES, 100 \u03bcg progesterone (P), 137 \u03bcg 17 \u03b1\u2010hydroxyprogesterone caproate, 10<jats:sup>\u22121<\/jats:sup> \u03bcg DES + 100 \u03bcg P, 2 \u03bcg DES + 100 \u03bcg P, 5 \u03bcg testosterone (T), 20 \u03bcg T, 20 \u03bcg 5\u03b1\u2010dihydrotestosterone (DHT), or sesame oil and were examined at 25 days, 35 days, or from 10 to 30 days of age. Three major cervicovaginal abnormalities were noted: adenosis (heterotopic columnar epithelium) in the fornices; altered common cervical canal (aberrantly simplified cervical lumen), and twin fornix (lateral branching of either or both fornices). Only DES, administered alone or in conjunction with P, resulted in adenosis and altered common cervical canal. At 25 days, all mice given 2 \u00d7 10<jats:sup>\u22121<\/jats:sup> \u03bcg DES showed adenosis. At 35 days, 75% of mice given 10<jats:sup>\u22121<\/jats:sup> \u03bcg or 2 \u03bcg DES showed adenosis. Adenosis incidence following 10<jats:sup>\u22121<\/jats:sup> \u03bcg DES was decreased by concomitant P. Altered common cervical canal was present in more than 90% of mice treated with DES alone at both 25 and 35 days; concomitant P lowered the incidence in mice receiving 10<jats:sup>\u22121<\/jats:sup> \u03bcg DES. Neonatal exposure to endogenous prolactin from a pituitary transplant did not modify the response. Twin fornix was not evident 10 days after neonatal androgen treatment. The frequency increased significantly by day 15 of treatment, reaching 100% by day 20; incidence then declined to 86% and 63% on days 25 and 30 after treatment, respectively. Thus, neonatal sex hormone administration results in various cervicovaginal changes, some transient, decreasing with age in young mice.<\/jats:p>","DOI":"10.1002\/tera.1420300214","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:51:25Z","timestamp":1118501485000},"page":"267-274","source":"Crossref","is-referenced-by-count":14,"title":["Cervicovaginal abnormalities in BALB\/c mice treated neonatally with sex hormones"],"prefix":"10.1002","volume":"30","author":[{"given":"Howard A.","family":"Bern","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen T.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L.","family":"Ostrander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Schoenrock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Graveline","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Plapinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"129","volume-title":"Development Effects of Diethylstilbestrol (DES) in Pregnancy","author":"Bern H. 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G.","year":"1981","journal-title":"Cancer Res."},{"key":"e_1_2_1_7_1","volume-title":"Developmental Effects of Diethylstilbestrol (DES) in Pregnancy","author":"Herbst A. L.","year":"1981"},{"key":"e_1_2_1_8_1","first-page":"67","article-title":"Long\u2010term effects of neonatal treatment with progesterone, alone and in combination with estrogen, on the mammary gland and reproductive tract of female BALB\/cfC3H mice","volume":"37","author":"Jones L. A.","year":"1977","journal-title":"Cancer Res."},{"key":"e_1_2_1_9_1","first-page":"2560","article-title":"Cervicovaginal and mammary gland abnormalities in BALB\/cCrgl mice treated neonatally with progesterone and estrogen, alone or in combination","volume":"39","author":"Jones L. A.","year":"1979","journal-title":"Cancer Res."},{"key":"e_1_2_1_10_1","first-page":"3988","article-title":"Long\u2010term effects on the female mouse genital tract associated with prenatal exposure of diethylstilbestrol","volume":"40","author":"McLachlan J. A.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_1_11_1","first-page":"81","volume-title":"Developmental Effects of Diethylstilbestrol (DES) in Pregnancy","author":"Noller K. L.","year":"1981"},{"key":"e_1_2_1_12_1","first-page":"507","article-title":"Adenosis\u2010like lesions and other cervicovaginal abnormalities in mice treated perinatally with estrogen","volume":"63","author":"Plapinger L.","year":"1979","journal-title":"J. Natl. Cancer Inst."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420300214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420300214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:10:06Z","timestamp":1697749806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420300214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,10]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,10]]}},"alternative-id":["10.1002\/tera.1420300214"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420300214","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,10]]}}}