{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T05:28:19Z","timestamp":1775194099703,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T00:00:00Z","timestamp":1116806400000},"content-version":"vor","delay-in-days":7416,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1985,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Long\u2010Evans hooded rat is widely used in experimental teratology. This study determines the teratogenicity of maternal Zn deficiency in the Long\u2010Evans hooded rat, and examines the effects of Zn deficiency on Zn, Fe, and Cu concentrations in maternal and fetal tissues. Dams were fed an egg white\u2010based diet containing 100 \u03bcg\/g Zn for 1 week prior to mating. At mating rats were fed diets with 0.5, 4.5, 9.0, or 100 \u03bcg\/g Zn ad lib, or 100 \u03bcg\/g Zn pairfed to 0.5 \u03bcg\/g Zn dams. Laparotomies were performed on day 21 of gestation. Live fetuses and resorptions were counted. Fetuses were weighed and examined for external malformations. Some fetuses were used for Zn, Fe, and Cudeterminations, others for internal or skeletal examination. Zn, Fe, and Cu levels were determined in maternal liver, kidney, and plasma. The 0.5 \u03bcg\/g Zn dams lost weight during pregnancy; 27% of implantation sites were resorbed, 91.7% of live fetuses were malformed, and fetal weight was low. There were no malformed fetuses in the 4.5 \u03bcg\/g Zn or 9.0 \u03bcg\/g Zn groups; litter weights were low in the 4.5 \u03bcg\/g Zn group. Tissue Zn was correlated with dietary Zn. Increased Fe concentration occurred in all maternal and fetal tissues in the 0.5 \u03bcg\/g Zn group. The teratogenicity of Zn deficiency in the Long\u2010Evans rat appears similar to that previously reported in the Sprague\u2010Dawley strain.<\/jats:p>","DOI":"10.1002\/tera.1420310111","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:11:39Z","timestamp":1118495499000},"page":"89-100","source":"Crossref","is-referenced-by-count":52,"title":["Zinc deficiency in pregnant Long\u2010Evans hooded rats: Teratogenicity and tissue trace elements"],"prefix":"10.1002","volume":"31","author":[{"given":"John M.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl L.","family":"Keen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucille S.","family":"Hurley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/102.3.343"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051270303"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-163-40792"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19730062"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02990451"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/98.4.449"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520292609115636"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/jn\/108.9.1431","article-title":"An interaction between zinc and vitamin A in pregnant and fetal rats","volume":"108","author":"Duncan J. 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