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Additionally, physical clamping of the uterine horns in addition to oral acetazolamide administration increases the frequency of forelimb ectrodactyly, suggesting that decreased uterine blood flow can potentiate acetazolamide teratogenesis. Since the vasoactive agents used in this study are reported to possoss uterine vasoconstrictive activity, a decrease in uterine blood flow is a plausible mechanism for the potentiative ability of these agents.<\/jats:p>","DOI":"10.1002\/tera.1420310213","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:15:24Z","timestamp":1118535324000},"page":"273-278","source":"Crossref","is-referenced-by-count":12,"title":["Potentiation of acetazolamide induced ectrodactyly in wistar rats by vasoactive agents and physical clamping of the uterus"],"prefix":"10.1002","volume":"31","author":[{"given":"Kenneth E.","family":"Ugen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"William J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod27.5.1231"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.132.3419.89-a"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1971.tb08057.x"},{"key":"e_1_2_1_5_1","first-page":"229","volume-title":"Practical Non\u2013parametric Statistics","author":"Conover W.","year":"1980"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051150210"},{"key":"e_1_2_1_7_1","first-page":"211","volume-title":"The Pharmacological Basis of Therapeutics","author":"Goodman L. 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