{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:26:56Z","timestamp":1783078016989,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,24]],"date-time":"2005-05-24T00:00:00Z","timestamp":1116892800000},"content-version":"vor","delay-in-days":7236,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1985,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is hypothesized that the known teratogen di(2\u2010methoxyethyl) phthalate (DMEP) acts by in vivo hydrolysis to 2\u2010methoxyethanol (2\u2010ME), also a known teratogen, which in turn is metabolized to methoxyacetic acid (MAA), the proximate teratogen. Teratological studies were conducted with Wistar rats, with the administration of these three agents on day 12 of gestation. On an equimolar dosage basis, DMEP, 2\u2010ME, and MAA were equally potent, which is consistent with the hypothesis. There was a striking similarity in the defects produced by these agents, mainly hydronephrosis, heart defects, and short limbs and tails. In particular all three agents produced unusual heart defects (dilated ductus arteriosus and dilated aortic arch) not seen with other agents, as well as ventral polydactyly, a rarely seen defect, suggesting teratogenic action by a common mechanism or component; 4\u2010methylpyrazole, an alcohol dehydrogenase inhibitor, provided significant protection against 2\u2010ME. This combination of effects strongly suggests that following the administration of DMEP, 2\u2010ME, or MAA, MAA is the proximate teratogen.<\/jats:p>","DOI":"10.1002\/tera.1420320105","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:54:42Z","timestamp":1118501682000},"page":"25-31","source":"Crossref","is-referenced-by-count":65,"title":["Teratogenicity of dimethoxyethyl phthalate and its metabolites methoxyethanol and methoxyacetic acid in the rat"],"prefix":"10.1002","volume":"32","author":[{"given":"E. J.","family":"Ritter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"W. J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Randall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(84)90051-1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2550040108"},{"key":"e_1_2_1_4_1","first-page":"229","volume-title":"Practical Non\u2010parametric Statistis","author":"Conover W.","year":"1980"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.413194"},{"key":"e_1_2_1_6_1","first-page":"495","article-title":"Characterization of subtle toxicity of certain plastic components used in manufacture of the polyvinyls","volume":"24","author":"Guess W. L.","year":"1967","journal-title":"Am. J. Hosp. 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J.","year":"1984","journal-title":"Teratology"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600610107"},{"key":"e_1_2_1_19_1","first-page":"61","article-title":"Refinements in rapid clearing technique in the KOH\u2010alizarin red S method for fetal bone","volume":"36","author":"Staples R. E.","year":"1964","journal-title":"Stain Technol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.3891\/acta.chem.scand.23-0255"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf60190a028"},{"key":"e_1_2_1_22_1","first-page":"251","volume-title":"Teratology: Principles and Techniques","author":"Wilson J. 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