{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T03:15:53Z","timestamp":1785467753815,"version":"3.56.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,24]],"date-time":"2005-05-24T00:00:00Z","timestamp":1116892800000},"content-version":"vor","delay-in-days":7236,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1985,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the homozygous state, the splotch (<jats:italic>Sp<\/jats:italic>) gene causes spina bifida and exencephaly. Close to 25% of the embryos from <jats:italic>Sp<\/jats:italic>\/ + \u00d7 <jats:italic>Sp<\/jats:italic>\/+ litters are affected. The frequency of these defects is significantly reduced by maternal treatment with 5 mg\/kg retinoic acid on day 9 of gestation. There is no significant increase in the resorption frequency with this treatment, indicating that the fall in the frequency of neural tube defects is not due to differential mortality of the affected fetuses. The effects of retinoic acid are time specific, with treatment at different times on day 9 having the greatest influence on either the anterior or posterior neuropore. Treatment on day 8 with the same dose of retinoic acid causes an increase in both resorptions and neural tube defects, although only the increase in the former was significant.<\/jats:p>","DOI":"10.1002\/tera.1420320112","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:54:42Z","timestamp":1118501682000},"page":"87-92","source":"Crossref","is-referenced-by-count":28,"title":["Reduction in the frequency of neural tube defects in splotch mice by retinoic acid"],"prefix":"10.1002","volume":"32","author":[{"given":"Carolyn M.","family":"Kapron\u2010Br\u00e1s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne G.","family":"Trasler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401270206"},{"key":"e_1_2_1_3_1","first-page":"155","volume-title":"The Biological Basis of Reproductive and Developmental Medicine","author":"Copp A. J.","year":"1983"},{"key":"e_1_2_1_4_1","first-page":"151","article-title":"Neural tube development in mutant (curly\u2010tail) and normal mouse embryos: The timing of posterior neuropore closure in vivo and in vitro","volume":"69","author":"Copp A. J.","year":"1982","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280318"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/67.1.97"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.152.3730.1766"},{"key":"e_1_2_1_8_1","first-page":"134","article-title":"Modulation of cell growth by retinoids and their possible mechanisms of action","volume":"43","author":"Jetten A. M.","year":"1984","journal-title":"Fed. Proc."},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000481042","article-title":"Thyroxin\u2010induced differential mortality of mouse embryos with cleft lip","volume":"2","author":"Juriloff D. M.","year":"1981","journal-title":"Dev. Pharmacol. Ther."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300118"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.9.5722"},{"key":"e_1_2_1_12_1","first-page":"64","article-title":"The effect of periconceptional supplementation of folic acid on the incidence of open neural tube defects in Golden Hamster embryos","volume":"27","author":"Moffa A. M.","year":"1983","journal-title":"Teratology"},{"key":"e_1_2_1_13_1","first-page":"5156","article-title":"Antiteratogenic effects of tumor inhibitors, caffeine, antipain, and retinoic acid in mice","volume":"43","author":"Nomura T.","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_1","first-page":"2740","article-title":"The function of vitamin A","volume":"42","author":"Olson J. A.","year":"1983","journal-title":"Fed. Proc."},{"key":"e_1_2_1_15_1","first-page":"133","article-title":"Offspring from transplanted ovaries of fetal mice homozygous for a lethal gene (Sp) that kills before birth","volume":"35","author":"Russell W. L.","year":"1950","journal-title":"Genetics"},{"key":"e_1_2_1_16_1","first-page":"306","article-title":"An essay on research into the causation and prevention of spina bifida","volume":"34","author":"Seller M. J.","year":"1981","journal-title":"Z. Kinderchir."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.20.3.164"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1979.0093"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970020409"},{"key":"e_1_2_1_20_1","volume-title":"The Principles and Practice of Statistics in Biological Research","author":"Sokal R. R.","year":"1981"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170213"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/2021029a0"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5181.1253"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420320112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420320112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T00:46:59Z","timestamp":1697849219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420320112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,8]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,8]]}},"alternative-id":["10.1002\/tera.1420320112"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420320112","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,8]]}}}