{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:14:30Z","timestamp":1791065670495,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,26]],"date-time":"2005-05-26T00:00:00Z","timestamp":1117065600000},"content-version":"vor","delay-in-days":7177,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1985,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Daily oral administration of ethinyl estradiol (0.02, 0.2, or 2.0 mg\/kg of body weight) to pregnant Jc1:ICR mice resulted in ovotestis and intra\u2010abdominal testis with persistent M\u00fcllerian duct and Wolffian duct in male fetuses and ovarian hypoplasia in female fetuses when it was given from day 11 through day 17 of gestation (before gonadal differentiation in the fetus). The ovotestis consisted of testicular and ovarian portions. In the testicular portion, a few solid seminiferous tubules containing spermatogonia, some with pachytene nuclei with Sertoli cells and compact interstitial tissue including Leydig cells, were seen. In the ovarian portion, pachytene nuclei were seen. The intra\u2010abdominal testis was smaller and contained more spermatogonia per tubule in cross section than the control testis. These findings suggest that in male fetuses ethinyl estradiol affects Sertoli cell differentiation resulting in suppression of M\u00fcllerian inhibiting factor. On the other hand, in the ovarian hypoplasia, the primordial follicles and follicular cells in a primordial follicle were significantly decreased in number, and the number of the degenerated primordial follicles was significantly increased. It seems likely that ethinyl estradiol affects the intimate contact between follicular cells and oocytes to cause degeneration of primordial follicles.<\/jats:p>","DOI":"10.1002\/tera.1420320210","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:53:14Z","timestamp":1118501594000},"page":"219-227","source":"Crossref","is-referenced-by-count":39,"title":["Gonadal dysgenesis induced by prenatal exposure to ethinyl estradiol in mice"],"prefix":"10.1002","volume":"32","author":[{"given":"Yoshiko","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahide","family":"Kihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Tanimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,26]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","article-title":"Follow\u2010up study of male and female offspring of DES\u2010exposed mothers","volume":"49","author":"Bibbo M.","year":"1977","journal-title":"Obstet. 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