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However, successive crops of cells gained the ability to phosphorylate with normal P:O ratios with pyruvate\u2010malate and succinate as substrates. Concentrations of cytochromes a + a<jats:sub>3<\/jats:sub> were markedly and significantly lower in homogenates of homozygous achondroplastic tissue culture cells than in homogenates of normal cells. Levels of cytochromes a + a<jats:sub>3<\/jats:sub> in the heterozygous achondroplastic cells were intermediate between the levels in normal cells and the homozygous achondroplastic cells. Activities of the mitochondrial oxidative systems (NADH, succinic and cytochrome oxidases) were not significantly lower in the achondroplastic cell preparations than in normal cell preparations under standard assay conditions (saturation levels of oxygen).<\/jats:p>","DOI":"10.1002\/tera.1420330103","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T14:55:04Z","timestamp":1118501704000},"page":"9-13","source":"Crossref","is-referenced-by-count":8,"title":["Studies of human achondroplasia: Oxidative metabolism in tissue culture cells"],"prefix":"10.1002","volume":"33","author":[{"given":"Bruce","family":"Mackler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Grace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith G.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010110"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(72)90020-3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.2106\/00004623-197153040-00011","article-title":"Oxygen tension in zones of the epiphyseal plate, the metaphysis and diaphysis","volume":"4","author":"Brighton C. 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