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Coadministration of the selective alpha\u20101\u2010adrenergic agonist phenylephrine significantly increased the incidence of acetazolamide\u2010induced right forelimb ectrodactyly while failing to induce the lesion when administered alone. Pretreatement with the alpha\u2010adrenergic antagonists phenoxybenzamine and prazosin prevented the phenylephrine\u2010induced increase in right forelimb ectrodactyly. In addition, treatment with either phenoxybenzamine or prazosin in the absence of stimulation with phenylephrine significantly decreased the incidence of acetazolamide\u2010induced ectrodactyly. The results suggest an adrenergic component in acetazolamide teratogenesis. Alterations in uterine blood flow are discussed as a plausible mechanism for the modification of the incidence of ectrodactyly by these adrenergic agents.<\/jats:p>","DOI":"10.1002\/tera.1420340208","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:00:32Z","timestamp":1118502032000},"page":"195-200","source":"Crossref","is-referenced-by-count":13,"title":["Acetazolamide teratogenesis in Wistar rats: Potentiation and antagonism by adrenergic agents"],"prefix":"10.1002","volume":"34","author":[{"given":"Kenneth E.","family":"Ugen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"William J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.132.3419.89-a"},{"key":"e_1_2_1_3_1","first-page":"514","article-title":"Prazosin, a selective antagonist of postsynaptic \u03b1\u2010adrenoceptors","volume":"59","author":"Cambridge D.","year":"1977","journal-title":"Br. 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