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On day 11 of gestation, dams were given intraperitoneal injections of 6\u2010mercaptopurine (27.5 mg\/kg). At term, dams fed the 1,000\u2010\u03bcg Zn per 1 g diet showed fewer drug\u2010induced deleterious effects on reproduction and embryogenesis than did those fed lower levels of zinc. Mineral analysis of maternal and fetal tissues revealed pronounced effects of 6\u2010mercaptopurine on metabolism of zinc, copper, iron, calcium, and magnesium. The results of this study indicate that 6\u2010mercaptopurine teratogenesis may be due in part to drug\u2010induced changes in mineral metabolism.<\/jats:p>","DOI":"10.1002\/tera.1420340312","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:00:33Z","timestamp":1118502033000},"page":"321-334","source":"Crossref","is-referenced-by-count":32,"title":["6\u2010mercaptopurine\u2010induced alterations in mineral metabolism and teratogenesis in the rat"],"prefix":"10.1002","volume":"34","author":[{"given":"Kenjie","family":"Amemiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl L.","family":"Keen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucille S.","family":"Hurley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420200208"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(85)90100-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051270303"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0162-0134(00)80126-9"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02990451"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1985.65.2.238"},{"key":"e_1_2_1_8_1","first-page":"898","article-title":"Biochemistry and pharmacology of purine analogues","volume":"26","author":"Elion G. 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