{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T20:51:34Z","timestamp":1698353494545},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,27]],"date-time":"2005-05-27T00:00:00Z","timestamp":1117152000000},"content-version":"vor","delay-in-days":6752,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The close linkage between the genes <jats:italic>Dominant hemimelia (Dh)<\/jats:italic> and <jats:italic>peptidase\u20103 (Pep\u20103)<\/jats:italic> has been determined in 65 informative matings with the recombination freqency of 3.8%. Progeny testing showed that non\u2010penetrance does occur in <jats:italic>Dh<\/jats:italic>\/+ adults. The presence of the \u201cslow\u201d and \u201cfast\u201d variants of <jats:italic>Pep\u20103<\/jats:italic> can be determined in homogenates of kidney tissue as well as in a portion of the day 10 and 11 embryos. In a litter of embryos born to an informative mating, those which are <jats:italic>Dh<\/jats:italic>\/<jats:italic>Dh<\/jats:italic>, <jats:italic>Dh<\/jats:italic>\/+, and +\/+ can be distinguished by the presence of the <jats:italic>Pep\u20103<\/jats:italic> allele known to be in coupling with the <jats:italic>Dh<\/jats:italic> gene. This technique makes it possible to identify and to study the limb malformations and other phenotypic effects of <jats:italic>Dh<\/jats:italic> during their development and before the limb deformity is visible.<\/jats:p>","DOI":"10.1002\/tera.1420340315","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:00:33Z","timestamp":1118502033000},"page":"353-357","source":"Crossref","is-referenced-by-count":7,"title":["Identification of Dh\/ + and Dh\/Dh embryos through close linkage of Dh and peptidase\u20103"],"prefix":"10.1002","volume":"34","author":[{"given":"Lewis B.","family":"Holmes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90006-1"},{"key":"e_1_2_1_3_1","first-page":"187","volume-title":"Genetic Variants and Strains of the Laboratory Mouse","author":"Green M. 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(1978; 1982)Personal communication."},{"issue":"1","key":"e_1_2_1_10_1","first-page":"69","article-title":"The effects of the Dh gene on limb morphogenesis in the mouse","author":"Rooze M. A.","year":"1967","journal-title":"Birth Defects"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02617955"},{"key":"e_1_2_1_12_1","first-page":"265","volume-title":"The Mouse: Its Reproduction and Development","author":"Rugh R","year":"1968"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300001166"},{"key":"e_1_2_1_14_1","first-page":"127","article-title":"The transition from oocyte\u2010coded to embryo\u2010coded glucose phosphate isomerase in the early mouse embryo","volume":"78","author":"West J. D.","year":"1983","journal-title":"J. Embryol. Exp. Morpol."},{"key":"e_1_2_1_15_1","first-page":"317","volume-title":"Limb Development and Reneration, Part A","author":"Zaleske D. 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