{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:27:00Z","timestamp":1781836020548,"version":"3.54.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T00:00:00Z","timestamp":1117238400000},"content-version":"vor","delay-in-days":6632,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a longitudinal prospective study of 1,529 women pregnant in 1974\u20131975, aspirin and acetaminophen were the two medications most frequently taken during the first half of pregnancy (46 and 41%, respectively). In a selected cohort of 421 offspring of these women, examined at 4 years of age, maternal aspirin use during the first half of pregnancy was significantly related to IQ and attention decrements in the exposed children. Multiple regression analyses were used to statistically adjust for a variety of potentially confounding factors including demographic characteristics, child characteristics, other exposures, and lifestyle\/environmental variables. Continuous doseresponse and step\u2010function parameterizations of aspirin exposure were both statistically significant and not clearly distinguishable from each other. The estimated aspirin effect is significantly greater, for girls than boys. Aspirin effects on offspring function were found in the absence of effects on physical size both at birth and at 4 years. Maternal acetaminophen use was not significantly related to child IQ or attention. As this exploratory research originated from observations of a data set gathered for other purposes, it would be desirable to have these findings replicated in other studies. Further follow\u2010up of the children at a later age is planned.<\/jats:p>","DOI":"10.1002\/tera.1420350207","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:01:36Z","timestamp":1118502096000},"page":"211-219","source":"Crossref","is-referenced-by-count":76,"title":["Aspirin and acetaminophen use by pregnant women and subsequent child IQ and attention decrements"],"prefix":"10.1002","volume":"35","author":[{"given":"Ann Pytkowicz","family":"Streissguth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Treder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Barr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.","family":"Shepard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Archie","family":"Bleyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Sampson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1001\/jama.1970.03170380023004","article-title":"Studies on the detection of adverse drug reactions in the newborn. II. The effects of prenatal aspirin on newborn hemostasis","volume":"213","author":"Bleyer W. A.","year":"1970","journal-title":"JAMA"},{"key":"e_1_2_1_3_1","volume-title":"Preschool IQ: Prenatal and Early Developmental Correlates","author":"Broman S. H.","year":"1975"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/newbio236211a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80078-7"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316542"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92777-4"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(71)80122-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2985-5_8"},{"key":"e_1_2_1_10_1","first-page":"188","volume-title":"Learning Disability\/Minimal Braib Dysfunction Syndrome: Research Perspectives and Applications","author":"Doyle R. B.","year":"1976"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1984.10477096"},{"key":"e_1_2_1_12_1","first-page":"421","volume-title":"Handbook of Teratology","author":"Edwards M. J.","year":"1977"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420260209"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420100312"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040104"},{"key":"e_1_2_1_16_1","first-page":"646","article-title":"The in vivo and in vitro action of sodium salicylate on rat ombryos","volume":"127","author":"McGarrity C.","year":"1978","journal-title":"J. Anat."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90549-4"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5748.523"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1542\/peds.67.6.785","article-title":"Central nervous system and facial defects associated with maternal hyperthermia at 4\u201314 weeks","volume":"67","author":"Pleet H. B.","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_1_20_1","first-page":"218","article-title":"Congenital malformations and environmental influence in pregnancy","volume":"23","author":"Richards I. D.","year":"1969","journal-title":"Br. J. Prev. Soc. Med."},{"issue":"5","key":"e_1_2_1_21_1","first-page":"52","article-title":"Neonatal intracranial hemorrhage and maternal use of aspirin","volume":"58","author":"Rumack C.","year":"1981","journal-title":"J. Obstet. Gynecol."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/4.1.37"},{"key":"e_1_2_1_23_1","first-page":"897","volume-title":"Handbook of Human Intelligence","author":"Siegler R. S.","year":"1982"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)93025-7"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/0012-1649.20.4.533"},{"key":"e_1_2_1_26_1","first-page":"223","article-title":"The Seattle longitudinal prospective study on alcohol and pregnancy","volume":"3","author":"Streissguth A. P.","year":"1981","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"e_1_2_1_27_1","volume-title":"Mental Retardation and Developmental Disabilities: Research, Education and Technology Transfer","author":"Streissguth A. P."},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198210073071502"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6866(1990)2:1<77::AID-TCM1770020108>3.0.CO;2-C"},{"key":"e_1_2_1_30_1","first-page":"315","article-title":"Experimental production of congenital malformations in rats by salicylate poisoning","volume":"35","author":"Warkany J.","year":"1959","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_31_1","volume-title":"Applied Linear Regression","author":"Weisberg S.","year":"1985"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198508083130603"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420350207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420350207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T06:47:03Z","timestamp":1695797223000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420350207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["10.1002\/tera.1420350207"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420350207","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}