{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:58:32Z","timestamp":1789268312705,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T00:00:00Z","timestamp":1117238400000},"content-version":"vor","delay-in-days":6571,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1987,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Valproic acid use during pregnancy results in an absolute risk for spina bifida of 1\u20132%. This increased risk is comparable to the recurrence risk for neural tube defects and warrants informed counselling and access to prenatal diagnosis. There is no substantial evidence that valproic acid use increases the risk for other specific major malformations above the increased risk due to maternal epilepsy. Valproic acid may cause a characteristic pattern of minor facial malformations. Further definition and confirmation are required, and the magnitude of the risk needs to be determined. There are inadequate data to assess the magnitude, if any, of the risks for postnatal growth abnormalities and developmental disabilities associated with the use of valproic acid during pregnancy. Birth\u2010defect monitoring programs and international collaboration among the staffs of monitoring programs played a major role in determining that valproic acid is a human teratogen.<\/jats:p>","DOI":"10.1002\/tera.1420350319","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:02:38Z","timestamp":1118502158000},"page":"465-473","source":"Crossref","is-referenced-by-count":237,"title":["Valproic acid"],"prefix":"10.1002","volume":"35","author":[{"given":"Edward J.","family":"Lammer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lowell E.","family":"Sever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Godfrey P.","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,28]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6360.190"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992288402300611"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90018-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.33.2.255"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91159-9"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198003203021204"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270106"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80429-5"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80517-8"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80172-9"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320190308"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6866(1990)2:1<61::AID-TCM1770020107>3.0.CO;2-O"},{"key":"e_1_2_1_14_1","first-page":"44","volume-title":"Contributions to Epidemiology and Biostatistics","author":"Flynt J. W.","year":"1979"},{"key":"e_1_2_1_15_1","unstructured":"Golden J. A. andG. F.Chernoff(1983)Anterior neural tube closure in the mouse: fuel for disagreement with the classical theory. Presented at the David W. Smith Conference on Malformations and Morphogenesis Hickory Knob S.C. 1982."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80743-3"},{"key":"e_1_2_1_17_1","first-page":"403","volume-title":"Epilepsy, Pregnancy, and the Child","author":"Granstrom M.\u2010L.","year":"1982"},{"key":"e_1_2_1_18_1","first-page":"397","volume-title":"Epilepsy, Pregnancy, and the Child","author":"Granstrom M.\u2010L.","year":"1982"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198404001-01276"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91387-2"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)90354-8"},{"key":"e_1_2_1_22_1","first-page":"425","volume-title":"Epilepsy, Pregnancy, and the Child","author":"Jager\u2010Roman E.","year":"1982"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-7314-2_1"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770010405"},{"key":"e_1_2_1_25_1","first-page":"313","volume-title":"Epilepsy, Pregnancy, and the Child","author":"Koch S.","year":"1982"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80750-1"},{"key":"e_1_2_1_27_1","first-page":"275","volume-title":"Epilepsy, Pregnancy, and the Child","author":"Lindhout D.","year":"1982"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)90557-9"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1984.tb05641.x"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(84)90243-7"},{"key":"e_1_2_1_31_1","first-page":"1","article-title":"Spina bifida e acido valproico: Risultati di un'analisi preliminare","volume":"47","author":"Mastroiacovo P.","year":"1982","journal-title":"Boll. Epi demiol. Nazionale (Ital.)"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90844-9"},{"key":"e_1_2_1_33_1","first-page":"438","article-title":"Valproate: A new cause of birth defects\u2013report from Italy and follow\u2010up from France","volume":"32","author":"MMWR","year":"1983","journal-title":"MMWR"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1980.tb04320.x"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90541-5"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92048-2"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1984.tb05632.x"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(84)80567-3"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-0590(83)80067-0"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-197713020-00001"},{"key":"e_1_2_1_41_1","first-page":"283","volume-title":"Epilepsy, Pregnancy, and the Child","author":"Rating D.","year":"1982"},{"key":"e_1_2_1_42_1","first-page":"565","article-title":"Valproic acid and spina bifida: A preliminary report\u2014France","volume":"31","author":"Robert E.","year":"1982","journal-title":"MMWR"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90908-4"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90656-6"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420250309"},{"key":"e_1_2_1_46_1","first-page":"243","volume-title":"Alpha\u2010fetoprotein and Congenital Disorders","author":"Sever L. E.","year":"1985"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90141-6"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060030113019"},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80987-0"},{"key":"e_1_2_1_50_1","first-page":"105","volume-title":"Clinical and Pharmacological Aspects of Sodium Valproate (Epilim) in the Treatment of Epilepsy","author":"Whittle B. A.","year":"1976"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420350319","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420350319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T20:23:07Z","timestamp":1697919787000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420350319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,6]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,6]]}},"alternative-id":["10.1002\/tera.1420350319"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420350319","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,6]]}}}