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As reported herein, phenylephrine also decreases maternal uterine blood flow in a dose\u2010response manner as measured by radioactive microsphere methodology. At the potentiative dose of 12.5 mg\/kg phenylephrine decreases uterine blood flow by 86.8% when compared to control. In turn, pretreatment with prazosin, a selective postsynaptic alpha\u20101\u2010adrenergic antagonist, prevents this large decrease in uterine blood flow and abolishes the potentiation of acetazolamide teratogenesis by phenylephrine. Although the effects of acetazolamide or acetazolamide + phenylephrine on uterine blood flow were not measured the data suggest a correlation between decreased uterine blood flow and potentiation of acetazolamide teratogenesis.<\/jats:p>","DOI":"10.1002\/tera.1420360117","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:04:31Z","timestamp":1118502271000},"page":"133-141","source":"Crossref","is-referenced-by-count":8,"title":["Reduction of uterine blood flow by phenylephrine, an alpha\u2010adrenergic agonist, in the day 11 pregnant rat: Relationship to potentiation of acetazolamide teratogenesis"],"prefix":"10.1002","volume":"36","author":[{"given":"Kenneth E.","family":"Ugen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"William J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-197405000-00002"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420260310"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1971.tb08057.x"},{"key":"e_1_2_1_5_1","first-page":"207","volume-title":"Statistics in Medicine","author":"Colton T.","year":"1974"},{"key":"e_1_2_1_6_1","first-page":"229","volume-title":"Practical Nonparametric Statistics","author":"Conover W.","year":"1980"},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/0002-9378(82)90649-4","article-title":"Effects of phenylephrine and sodium salicylate on maternal and fetal cardiovascular indices and blood oxygenation in sheep","volume":"143","author":"Cottle M. 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