{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:14:42Z","timestamp":1764688482576},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T00:00:00Z","timestamp":1117238400000},"content-version":"vor","delay-in-days":6357,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To examine the effects of vitamin A administered during the preimplantation period, pregnant C3H mice were exposed to teratogenic doses of the vitamin 60 h after copulation. Fetuses were examined for gross abnormalities on the 18th day of gestation and viability, cell number, mitotic index, and chromosome structure were assessed in 81\u2010h blastocysts to determine whether embryotoxic effects were apparent in the preimplantation embryo. There was a reduction in the fetal weight of 18\u2010day fetuses treated in this manner with 15,000 and 30,000 IU vitamin A (p &lt; 0.0003 in each case), and doses of 10,000 IU and greater were associated with a significantly higher incidence of gross abnormalities. Malformations included exophthalmos, anophthalmia, microphthalmia, exencephaly, exomphalos, and limb defects. Administration of 30,000 IU vitamin A resulted in resorption and intrauterine death in 70% of cases. There was no indication that vitamin A adversely affected 81\u2010h blastocyst viability, cell number, mitotic index, and chromosome structure. The findings suggest that the teratogenic effects that were noted later in fetal life were the result of an action on the developing fetus of the vitamin at a stage later than 81\u2010h and are consistent with the relative resistance of the preimplantation embryo to toxic injury. Persistence of vitamin A, either in the mother or the embryo, is the most likely explanation for the later expression of toxic injury, which is characteristic of the effects that are noted as a result of exposure to the teratogen during the period of organogenesis.<\/jats:p>","DOI":"10.1002\/tera.1420370103","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:05:50Z","timestamp":1118502350000},"page":"7-11","source":"Crossref","is-referenced-by-count":12,"title":["The effects of in vivo administration of teratogenic doses of vitamin A during the preimplantation period in the mouse"],"prefix":"10.1002","volume":"37","author":[{"given":"P. I.","family":"Pillans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. I.","family":"Folb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. F.","family":"Ponzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,28]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"468","article-title":"The action of various agents upon the rabbit embryo","volume":"9","author":"Adams C. E.","year":"1961","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/244333a0"},{"key":"e_1_2_1_4_1","first-page":"279","article-title":"The effects of vitamin A and citral on epithelial differentiation in vitro. 1. The chick tracheal epithelium","volume":"11","author":"Aydelotte M. B.","year":"1963","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_5_1","first-page":"621","article-title":"The effects of vitamin A and citral on epithelial differentiation in vitro. 2. The chick esophageal and corneal epithelia and epidermis","volume":"11","author":"Aydelotte M. B.","year":"1963","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408447909043651"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92344-X"},{"key":"e_1_2_1_8_1","first-page":"1","article-title":"Experimental production of congential malformations in strains of inbred mice by maternal treatment with hypervitaminosis A","volume":"38","author":"Kalter H.","year":"1961","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010308"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770060104"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901310103"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0580189"},{"key":"e_1_2_1_13_1","first-page":"241","article-title":"Morphogenesis of the malformations induced in rat embryos by maternal hypervitaminosis A","volume":"113","author":"Morriss G. M.","year":"1972","journal-title":"J. Anat."},{"key":"e_1_2_1_14_1","unstructured":"Rosa F. W. A. L. Wilk S. R.Joshi F.KelseyandG.Troendle(1984)Teratology of hypervitaminosis A. 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