{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:39:51Z","timestamp":1773002391277,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,5,31]],"date-time":"2005-05-31T00:00:00Z","timestamp":1117497600000},"content-version":"vor","delay-in-days":6269,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1988,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of multiple maternal subcutaneous injections of tellurium dioxide (TeO<jats:sub>2<\/jats:sub>) suspended in olive oil (0\u20131,000 \u03bcmol\/kg) from day 15 to day 19 of gestation were evaluated in the Wistar rat. External and internal soft\u2010tissue examinations were performed on day 20 fetuses. Multiple maternal injections, at doses higher than 10 \u03bcmol\/kg, resulted in a dose\u2010related appearance of hydrocephalus, edema, exophthalmia, ocular hemorrhage, umbilical hernia, undescended testis, and small kidneys in fetuses on day 20 of gestation. At 500 \u03bcmol\/kg, reduction in maternal weight gain was also observed. At this level, the incidence of the above anomalies was 100%. The 100 \u03bcmol\/kg dose of Te, which did not produce apparent maternal toxic responses, resulted in a 100% incidence of hydrocephalus and edema but no fetal mortality. Thus, tellurium can be teratogenic to the rat fetus without concomitant maternal toxicity. Also, the fetal period may be more sensitive than the organogenic period for the induction of hydrocephalus. Such evidence is consistent with the development of the choroid plexus and an effect of TeO<jats:sub>2<\/jats:sub> on the production\/resorption of cerebrospinal fluid.<\/jats:p>","DOI":"10.1002\/tera.1420370404","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:07:32Z","timestamp":1118502452000},"page":"307-316","source":"Crossref","is-referenced-by-count":25,"title":["Teratogenicity of tellurium dioxide: Prenatal assessment"],"prefix":"10.1002","volume":"37","author":[{"given":"Rogelio E.","family":"Perez\u2010D'Gregorio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard K.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,31]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"325","article-title":"Experimental congenital hydrocephalus. 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