{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:05:53Z","timestamp":1760954753441},"reference-count":66,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":6209,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bendectin, composed of doxylamine succinate and pyridoxine HCl (1:1), is an antinauseant previously prescribed for nausea and vomiting during pregnancy. The present study examined the maternal and developmental effects of Bendectin (0, 200, 500, or 800 mg\/kg\/day, po) administered to timed\u2010pregnant CD rats (36\u201341\/group) during organogenesis (gestational days [gd] 6\u201315). At death (gd 20), all live fetuses were examined for external, visceral, and skeletal abnormalities. At 500 and 800 mg\/kg\/day, maternal toxicity included reduced food consumption during treatment and for the gestation period, increased water consumption in the posttreatment period, reduced weight gain during treatment, and sedation; water consumption was reduced during treatment and for the gestation period, and maternal mortality (17.1%) was observed only at the high dose. Developmental toxicity included reduced prenatal viability (800 mg\/kg\/day) and reduced fetal body weight\/litter (500 and 800 mg\/kg\/day). In addition, reduced ossification of metacarpals (800 mg\/kg\/day), phalanges of the forelimbs (500 and 800 mg\/kg\/day), and of caudal vertebral centra (all doses) was observed. No increase in percent malformed live fetuses\/litter was observed. The proportion of litters with one or more malformed fetuses was higher than vehicle controls only at 800 mg\/kg\/day, with short 13th rib (to which the test species is predisposed) as the predominant observation. By contrast, a positive control agent (nitrofen, 50 mg\/kg\/day, po, 14 dams) produced 85% malformed fetuses\/litter with the predominant malformation being diaphragmatic hernia. In conclusion, the incidence of litters with one or more malformed fetuses was increased only at a dose of Bendectin which produced maternal mortality (17.1%) and other indices of maternal and developmental toxicity (see Discussion).<\/jats:p>","DOI":"10.1002\/tera.1420370603","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:08:38Z","timestamp":1118502518000},"page":"539-552","source":"Crossref","is-referenced-by-count":14,"title":["Developmental toxicity evaluation of Bendectin in CD rats"],"prefix":"10.1002","volume":"37","author":[{"given":"Rochelle W.","family":"Tyl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine J.","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa C.","family":"Marr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole A.","family":"Kimmel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420200208"},{"key":"e_1_2_1_3_1","unstructured":"Anonymous (1982) FDA ponders change in Bendectin label; Birth defects studied.The Wall Street Journal Monday June 28 p.3."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420220107"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420260308"},{"key":"e_1_2_1_6_1","volume-title":"Physician's Desk Reference","author":"Baker C. 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