{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T04:34:50Z","timestamp":1774067690364,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":6209,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1988,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The fungicide dinocap is currently used in the control of powdery mildew. We have reported that dinocap is teratogenic in the CD\u20101 mouse, causing cleft palate, otolith defects, and fetal weight deficits well below maternotoxic dose levels. In this study the maternal and fetal toxicity of dinocap was determined in the Sprague\u2010Dawley rat and Syrian golden hamster, and adult\u2010to\u2010developmental (A\/D) toxicity ratios were calculated and compared with the previously established A\/D ratio of dinocap in the mouse. Dinocap in corn oil was admisnistered by gavage to pregnant rats on gestation days 7\u201320 (0, 100, 150, 200 mg\/kg\/day) and to hamsters on gestation days 7\u201314 (0, 12.5, 25, 50, 75, 100, 200 mg\/kg\/day). Dams were killed on day 21 (rat) or day 15 (hamster), and litters were removed, counted, and weighed; half of each litter was necropsied for soft tissue defects, and the remaining half was processed for skeletal examination. In the rat, maternal extrauterine weight gain was significantly affected at 150 and 200 mg\/kg\/ day, relative liver weight was elevated at 100 mg\/kg\/day and above, and fetal weight was lower at 150 and 200 mg\/kg\/day. In the hamster, maternal extrauterine weight was lower at 12.5 mg\/kg\/day and above; fetal weight was reduced, and the incidence of dilated renal pelvis was higher, at 25 mg\/kg\/day and above. Thus the A\/D ratios for dinocap in the rat and hamster are similar, approximately 1. Our previous studies have demonstrated that dinocap is teratogenic in the mouse, with an A\/D ratio in the range of 8\u201316 in this species. The basis for the species\u2010specific teratogenicity and inconsistent A\/D ratio of dinocap is unknown.<\/jats:p>","DOI":"10.1002\/tera.1420370604","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:08:38Z","timestamp":1118502518000},"page":"553-559","source":"Crossref","is-referenced-by-count":18,"title":["The mouse teratogen dinocap has lower A\/D ratios and is not teratogenic in the rat and hamster"],"prefix":"10.1002","volume":"37","author":[{"given":"John M.","family":"Rogers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Barbee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesley M.","family":"Burkhead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Rushin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Kavlock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770060105"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10915818409018028"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350314"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","unstructured":"Johnson E. M. R. M. German B. E. G.GabelandM. E.George(1982) The Hydra attenuata system for detection of teratogenic hazards.Teratogenesis Carcinog. Mutagen. 263\u2013276.","DOI":"10.1002\/1520-6866(1990)2:3\/4<263::AID-TCM1770020308>3.0.CO;2-I"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770070308"},{"key":"e_1_2_1_7_1","first-page":"887","article-title":"Gas chromatographic determination of total active ingredient content of Karathane Technical and Karathane WD. I. Development of the method","volume":"53","author":"Kurtz C. P.","year":"1970","journal-title":"J. Assoc. Off. Anal. Chem."},{"key":"e_1_2_1_8_1","first-page":"85","article-title":"Dinocap pharmacokinetic study in female rabbits","volume":"6","author":"Longacre S. L.","year":"1986","journal-title":"Toxicologist"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770070310"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770060504"},{"key":"e_1_2_1_11_1","first-page":"1141","article-title":"Otolith development in mice prenatally exposed to dinocap and comparison of effects in hamsters","volume":"46","author":"Rogers J. M.","year":"1987","journal-title":"Fed. Proc."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770070402"},{"key":"e_1_2_1_13_1","volume-title":"SAS Users Guide: Statistics","author":"SAS Institute, Inc.","year":"1982"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770070307"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420370604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420370604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T11:33:26Z","timestamp":1695814406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420370604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1988,6]]}},"alternative-id":["10.1002\/tera.1420370604"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420370604","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6]]}}}