{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:08:31Z","timestamp":1767989311290,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":6148,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1988,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the effect of amino acids and the tripeptide glutathione (GSH) on tissue uptake of methylmercury (MeHg) in the developing rat fetus in utero, pregnant rats were continuously infused into the external jugular vein with 0.1 mM L\u2010cysteine, 0.1 mM L\u2010leucine, 0.1 mM GSH or saline commencing on day 17 of gestation. This was followed at 24, 48, and 72 hours by external jugular infusion of 50 \u03bcM [<jats:sup>203<\/jats:sup>Hg]\u2010MeHgCl administered in 1 ml over 1 hour. Pups were surgically removed from the uterus on gestational day 21. Whole body, brain, kidney, liver, and placental <jats:sup>203<\/jats:sup>Hg radioactivity was measured by means of gamma\u2010spectrometry. Brain <jats:sup>203<\/jats:sup>Hg concentration in pups exposed in utero to L\u2010cysteine was significantly higher compared with pups exposed to saline (<jats:italic>P<\/jats:italic> &lt;0.05). Brain <jats:sup>203<\/jats:sup>Hg concentration in pups exposed in utero to L\u2010leucine and GSH was significantly depressed compared with pups exposed to saline (<jats:italic>P<\/jats:italic> &lt;0.05). Kidney <jats:sup>203<\/jats:sup>Hg concentration was not significantly changed in all treatment groups compared with controls. Liver <jats:sup>203<\/jats:sup>Hg concentration was significantly depressed in L\u2010leucine\u2010 and GSH\u2010treated pups compared with controls (<jats:italic>P<\/jats:italic> &lt;0.05). Placental <jats:sup>203<\/jats:sup>Hg concentration was not affected by any treatment compared with controls. These effects occurred despite no difference in total <jats:sup>203<\/jats:sup>Hg body burden among pups, irrespective of the treatment. In addition, infusion with L\u2010cysteine resulted in a significant increase in <jats:sup>203<\/jats:sup>Hg brain concentration in dams compared with controls, and <jats:sup>203<\/jats:sup>Hg brain concentration in L\u2010leucine\u2010 and GSH\u2010treated dams was significantly depressed compared with controls. Thus <jats:sup>203<\/jats:sup>Hg distribution in both adult and developing animals is altered by chronic amino acid or GSH infusions and suggests that MeHg uptake may be mediated through the formation of a cysteine\u2010MeHg complex which is transported across the blood\u2010brain barrier by the neutral amino acid carrier transport system.<\/jats:p>","DOI":"10.1002\/tera.1420380207","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:11:03Z","timestamp":1118502663000},"page":"145-155","source":"Crossref","is-referenced-by-count":39,"title":["Distribution of mercury 203 in pregnant rats and their fetuses following systemic infusions with thiol\u2010containing amino acids and glutathione during late gestation"],"prefix":"10.1002","volume":"38","author":[{"given":"Michael","family":"Aschner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Clarkson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1070","article-title":"Perinatal methylmercury poisoning in Iraq","volume":"130","author":"Zaki L. 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