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Rats were treated on day 12 of gestation (day 0 = sperm in vaginal smear) with a single intraperitoneal injection of 30 mg DMPT\/kg. Fetuses were examined on each subsequent day of gestation for external and skeletal abnormalities. Standard soft tissue examinations were performed on day\u201020 fetuses. A high percentage (\u226580%) of treated litters contained numerous fetuses with micrognathism, cleft palates, syndactyly, adactyly, and misshapen digits and limbs. Lordosis, cerebellar and cerebral hypoplasia, decreased fetal size, and generalized delayed ossification were also observed. Dams exposed to DMPT had decreased food consumption and weight gains, although clinicopathologic and histopathologic evaluations failed to indicate other evidence of maternal toxicity. DMPT caused numerous permanent structural alterations that were not attributed to maternal toxicity.<\/jats:p>","DOI":"10.1002\/tera.1420390107","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:13:05Z","timestamp":1118502785000},"page":"53-61","source":"Crossref","is-referenced-by-count":8,"title":["Teratogenicity of 3,3\u2010dimethyl\u20101\u2010phenyltriazene in the rat: Gross malformations including micrognathism"],"prefix":"10.1002","volume":"39","author":[{"given":"Anthony A.","family":"Frank","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn A.","family":"Kazacos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420330312"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-7992(87)90025-X"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-90-22074"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520292609115636"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(81)90288-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1139\/y81-193"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.2307\/2346487"},{"key":"e_1_2_1_9_1","first-page":"171","article-title":"Differential staining of cartilage and bone in fetal mouse skeleton by alcian blue and alizarin red S","volume":"16","author":"Inouye M.","year":"1976","journal-title":"Cong. 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