{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:25:50Z","timestamp":1757543150128},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":5936,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The synthetic estrogens, diethylstibestrol (DES) and ethynylestradiol (EE<jats:sub>2<\/jats:sub>), are more potent than 17\u03b2\u2010estradiol (E<jats:sub>2<\/jats:sub>) in inducing uterine weight gain in the neonatal rat, due to the binding of E<jats:sub>2<\/jats:sub> to serum \u03b1\u2010fetoprotein (AFP). However, all three hormones are equipotent in inducing neonatal uterine ornithine decarboxylase (ODC) activity. The present study assessed estrogen potency in fetal rats. Pregnant CD rats were injected sc. daily on gestation days (GD) 16\u201320 with DES, EE<jats:sub>2<\/jats:sub>, or E<jats:sub>2<\/jats:sub> in sesame oil. Both DES and EE<jats:sub>2<\/jats:sub>, but not E<jats:sub>2<\/jats:sub>, significantly increased uterine weight at birth, to more than twice that of controls. In addition, implants which continuously release E<jats:sub>2<\/jats:sub> only slightly increased uterine weight at birth. Alternatively, dams were given a single estrogen injection on GD 20 and were sacrificed at various times after injection. Peak fetal uterine ODC activity occurred at 6\u20138 hours after maternal injection for all three estrogens. E<jats:sub>2<\/jats:sub> had a relative potency about tenfold less than either DES or EE<jats:sub>2<\/jats:sub> in stimulating fetal ODC activity, in contrast to equal potencies of the three estrogens in the postnatal rat uterus. Similar patterns were found following direct fetal injection with E<jats:sub>2<\/jats:sub> or DES. In summary, these data demonstrate a transplacental induction of fetal uterine ODC activity and uterine weight gain by both DES and EE<jats:sub>2<\/jats:sub>. In addition, the lack of correlation between these endpoints in response to E<jats:sub>2<\/jats:sub> suggests that they may be useful as selective indicators of potential toxicity of both natural and synthetic estrogens.<\/jats:p>","DOI":"10.1002\/tera.1420390307","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:07:07Z","timestamp":1118549227000},"page":"253-260","source":"Crossref","is-referenced-by-count":4,"title":["Transplacental estrogen responses in the fetal rat: Increased uterine weight and ornithine decarboxylase activity"],"prefix":"10.1002","volume":"39","author":[{"given":"James R.","family":"Harmon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William S.","family":"Branham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016348109154132"},{"key":"e_1_2_1_3_1","first-page":"103","article-title":"Use of the neonatal mouse in studying long\u2010term effects of early exposure to hormones and other agents","volume":"1","author":"Bern H. 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