{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:34:46Z","timestamp":1760204086149},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":5844,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1989,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of sera from different types of human diabetes (type I with and without ketoacidosis; type II treated with insulin or Daonil or untreated) on the in vitro development of early preimplantation mouse embryos were studied. In controls, 20% of blastocysts failed to develop successfully when grown for 72 h in RPMI medium supplemented with 10% fetal bovine serum and 50% nondiabetic human serum. In experiments using 50% diabetic serum, the highest embryotoxic effect was found in type\u2010I diabetes with and without ketoacidosis: The percents of undeveloped embryos were 66 and 58, respectively. In type\u2010II diabetes, embryotoxic effects were found among all studied types: The percent of undeveloped blastocysts varied from 36% in insulin\u2010treated type\u2010II diabetes to 44% in untreated type\u2010II diabetes. A high correlation was found between the number of undeveloped embryos and the blood concentrations of metabolic diabetic factors: glucose (r = .53\u2013.64 in type\u2010I diabetes), B\u2010HOB (r = .7\u2013.77 in type\u2010II diabetes untreated or treated with Daonil), acetoacetate (r = .66 in insulin\u2010treated type\u2010II diabetes), and HbA<jats:sub>1c<\/jats:sub> (r = .89 in insulin\u2010treated type\u2010II diabetes or .99 in Daonil\u2010treated type\u2010II diabetes). A concentration of 80% serum was embryotoxic when obtained from nondiabetic or from diabetic human. The possible role of diabetic metabolic factors in causing increased risk of spontaneous abortions and infertility among diabetic women is discussed.<\/jats:p>","DOI":"10.1002\/tera.1420390609","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:13:26Z","timestamp":1118495606000},"page":"581-589","source":"Crossref","is-referenced-by-count":10,"title":["Effects of human diabetic serum on the in vitro development of mouse preimplantation embryos"],"prefix":"10.1002","volume":"39","author":[{"given":"Igor","family":"Zusman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perhija","family":"Yaffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asher","family":"Ornoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"13A","article-title":"The effects of serum from women with recurrent abortions on the in vitro development of mouse blastocysts","volume":"38","author":"Abir R.","year":"1988","journal-title":"Teratology"},{"key":"e_1_2_1_3_1","first-page":"E234","article-title":"Fetal fuels V. 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