{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:07:40Z","timestamp":1764781660019},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":5814,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preaxial polydactyly of the fore\u2010and hindlimbs was found in Wistar\u2010derived rats in 1978. Genetic analysis indicated that the polydactyly was due to the effects of an autosomal recessive gene (gene symbol; pd) Polydactylous and one to three preaxial extra digits (six to eight digits) in the hindlimbs. Skeletal examination revealed the presence of the extra carpal, metacarpal, and phalangeal bones that seemed to be complete or incmplete duplication of the navicular, greater multangular, first metacarpal, and phalanges of digit I in the forelimbs. In the hindlimbs, extra tarsal, metatarsal, and phalangeal bones were also observed preaxially. These extra elements seemed to be mirror\u2010image duplications of the talus navicular, second cuneiform, third cuneiform, cuboid, and metatersals and phakanges of digits II\u2010V with the absence of the first cuneoform, tibnials, first metatarsal, and phalanges of digit I. In addition, morphological changes were observed in the humerus, radius, and ulna in hte forlimbs and femur, tibia, and fibula in the hindlimbs. Especially in the radius andtibia, thickening and bifurcation were found, indicating incomplete duplication of these bones. Based on these findings, the limb anomaly was classfied as preaxial carpometacarpal\/tarsometatarsal\u2010type polydactyly with incomplete duplication of the radius and tibia. The mutan rats had other associated anomalies such as accessory spleens and cryptorchism. The males are sterile, whereas the females breed normally.<\/jats:p>","DOI":"10.1002\/tera.1420400110","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:41:33Z","timestamp":1118504493000},"page":"77-84","source":"Crossref","is-referenced-by-count":11,"title":["Anatomical features associated with <i>preaxial duplication<\/i> (<i>pd<\/i>): A recessive mutation in the rat"],"prefix":"10.1002","volume":"40","author":[{"given":"Masahiro","family":"Kaneda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Shirasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"369","article-title":"Dominant polydactyly\u2010luxate syndrome (DPLS)\u2013 A new mutant of the Norway rat","volume":"24","author":"B\u00edl\u00e1 V.","year":"1978","journal-title":"Folia Biol. 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