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Macroscopically, there were four expanded and three distorted brains out of 19 surviving embryos, whereas no brain abnormality was noticed in 13 embryos injected with culture medium instead of MCMV in the same way. Histopathological examination showed hydrocephalic lesions with strong dilatation of the ventricles and atrophy of the cerebral cortex, and inflammatory lesions with granulomatous proliferation of the ventricular walls with disappearance of the cortical zonation. Immunohistochemically, MCMV\u2010induced nuclear antigen\u2010positive cells were frequently observed in the wall of the ventricles and occasionally scattered in the cerebral cortex, white matter, and the nucleus basalis. Some fetuses injected with MCMV in the same way were recovered from the abdominal cavities on day 18 of gestation and transferred to foster nurse mothers. They showed massive cerebral necrosis after feeding for 9 days after birth. Brain abnormalities of mouse embryos after intraventricular injection with MCMV may provide an experimental model of brain damage induced by congenital cytomegalovirus infection.<\/jats:p>","DOI":"10.1002\/tera.1420400212","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:41:47Z","timestamp":1118504507000},"page":"181-189","source":"Crossref","is-referenced-by-count":22,"title":["Brain abnormalities induced by murine cytomegalovirus injected into the cerebal ventricles of mouse embryos exo utero"],"prefix":"10.1002","volume":"40","author":[{"given":"Ichiro","family":"Naruse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Tsutsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050150092023"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/148.5.836"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1128\/jvi.57.3.1149-1154.1986","article-title":"Murine cytomegalovirus infection of mouse testes","volume":"57","author":"Baskar J. 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