{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:34:48Z","timestamp":1760204088360},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":5722,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1989,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of nifedipine (40\u2013100 \u03bcmol\/kg), nitrendipine (40 and 80 \u03bcmol\/kg), hydralazine (381 and 763 \u03bcmol\/kg), felodipine (12 \u03bcmol\/kg), and the pharmacologically inactive first\u2010step metabolite of felodipine, H152\/37 (80 \u03bcmol\/kg) were studied in rabbits (New Zeeland White) after oral administration on day 16 of gestation. The vasodilating drugs\u2014nifedipine, nitrendipine, felodipine, and hydralazine\u2014all induced digital defects in the fetuses. The defects consisted of a reduction, absence, or abnormal structure of the distal phalanx of especially the fourth digit on the hind paw(s). Histologically, a disturbed differentiation of the cartilage, and secondarily also of the ossification centre and joint structure of the distal phalanx, was observed. In contrast, no digital abnormalities were observed after administration of vehicle or H152\/37. The findings that vasodilators with different structures, like dihydropyridines and hydralazine, induced the same type of digital defects strongly suggest that the observed phalangeal defects are secondary to pharmacological action, and not related to chemical structure. A decrease in uteroplacental blood flow, caused by excessive hypotension, is discussed as the most probable mechanism underlying the observed defects.<\/jats:p>","DOI":"10.1002\/tera.1420400407","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:43:08Z","timestamp":1118504588000},"page":"351-358","source":"Crossref","is-referenced-by-count":55,"title":["Digital defects induced by vasodilating agents: Relationship to reduction in uteroplacental blood flow"],"prefix":"10.1002","volume":"40","author":[{"given":"Bengt R. G.","family":"Danielsson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Reiland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Rundqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaretha","family":"Danielson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.132.3419.89-a"},{"key":"e_1_2_1_3_1","first-page":"257","article-title":"Mechanism of serotonin induced abortion in rats","volume":"81","author":"Craig J. M.","year":"1966","journal-title":"Arch. Pathol."},{"key":"e_1_2_1_4_1","first-page":"378","article-title":"Calcification of the rabbit fetal skeleton","volume":"50","author":"Danielson M.","year":"1986","journal-title":"Growth"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520292609115636"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051150210"},{"key":"e_1_2_1_7_1","first-page":"2245","article-title":"Effects of nifedipine on rat fetuses","volume":"17","author":"Fukunishi K.","year":"1980","journal-title":"Med. Consult. New Remed."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070303"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0630163"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(70)90418-7"},{"key":"e_1_2_1_11_1","unstructured":"Leist K. H. andJ.Grauwiler(1972)Influence of the developmental stage on embryotoxicity following uterine vessel clamping in the rat. 2nd Conference European Teratology Society Prague."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420100109"},{"key":"e_1_2_1_13_1","first-page":"79","article-title":"Cardiovascular and uterine blood flow changes during nicardipine HC J tocolysis in the rabbit","volume":"169","author":"Lirette M.","year":"1987","journal-title":"Obstet. Gynecol."},{"key":"e_1_2_1_14_1","unstructured":"Lundgren Y. P. Thalen andM.Nordlander(1989)Effects of felodipine on uteroplacental blood flow in normotensive rabbits. Clin. Exp. Hypertension (submitted)."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1967.tb00414.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198501000-00002"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150307"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0250553"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1966.sp007943"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198836040-00002"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310213"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340208"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350212"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420400407","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420400407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:51:44Z","timestamp":1697979104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420400407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,10]]}},"alternative-id":["10.1002\/tera.1420400407"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420400407","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10]]}}}