{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T12:29:42Z","timestamp":1782563382494,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":5691,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The susceptible period of nitrous oxide (N<jats:sub>2<\/jats:sub>O) teratogenicity was studied in 170 Sprague\u2010Dawley rats. Seven groups of 20 timed\u2010pregnant rats were exposed to 60% N<jats:sub>2<\/jats:sub>O for 24 hours on each of days 6\u201312 of gestation; a control group of 30 timed\u2010pregnant rats was exposed to air on day 9. On day 20 of gestation, dams were killed and reproductive indices were determined; their fetuses were subsequently examined for external, skeletal, and visceral abnormalities. There were no differences among the groups in the number of implantations and live fetuses, mean fetal weight, and sex ratio. The incidence of fetal wastage was higher than control in N<jats:sub>2<\/jats:sub>O\u2010treated groups exposed on days 8 and 11 of gestation. Skeletal malformations of the ribs and vertebrae were increased following exposure on day 9 of gestation. However, the specific minor anomaly, cervical rib, was increased only following exposure on day 8 of gestation. The incidences of right\u2010sided aortic arch and left\u2010sided umbilical artery, abnormalities indicative of altered laterality, were increased following exposure on day 8 of gestation. Nitrous oxide administration during organogenesis causes several reproductive defects by mechanisms which remain to be determined.<\/jats:p>","DOI":"10.1002\/tera.1420400505","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:45:26Z","timestamp":1118504726000},"page":"439-444","source":"Crossref","is-referenced-by-count":32,"title":["Susceptible period of nitrous oxide teratogenicity in sprague\u2010dawley rats"],"prefix":"10.1002","volume":"40","author":[{"given":"Masahiko","family":"Fujinaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Baden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I.","family":"Mazze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1051270303"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420260310"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/214146a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198712000-00014"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/58.5.528"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7434002"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300213"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/59.10.1291"},{"key":"e_1_2_1_10_1","first-page":"E13","volume-title":"Halothane prevents nitrous oxide teratogenicity in Sprague\u2010Dawley rats; folinic acid does not","author":"Mazze R. I.","year":"1988"},{"key":"e_1_2_1_11_1","unstructured":"Shardein J. L.(1985)Measuring and assessing the result of testing: Nonstatistical methods. In: Refresher Course. Education Committee of the Teratology Society eds. pp.E13\u2013E19."},{"key":"e_1_2_1_12_1","first-page":"308","volume-title":"Toxicity of Anesthetics","author":"Shepard T. H.","year":"1968"},{"key":"e_1_2_1_13_1","first-page":"42","article-title":"Energy metabolism in early mammalian embryos","volume":"4","author":"Shepard T. H.","year":"1970","journal-title":"Dev. Biol."},{"key":"e_1_2_1_14_1","first-page":"61","article-title":"Refinements in rapid clearing technique in KOH\u2010alizarin red S method for fetal bone","volume":"43","author":"Staples R. E.","year":"1968","journal-title":"Stain Technol."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420400505","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420400505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T07:17:04Z","timestamp":1697959024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420400505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1002\/tera.1420400505"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420400505","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}