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This specific malformation has previously been associated with the administration of acetazolamide to rodents; however, several agents can induce this same defect including other carbonic anhydrase inhibitors, carbon dioxide, cadmium, ethanol, ammonium chloride, and 13\u2010cis retinoic acid. The relative potency of the three agents indicates no direct relationship to the pK<jats:sub>a<\/jats:sub> of the acid. Other than ectrodactyly, each of the anticonvulsant agents induced a compound\u2010specific spectrum of malformations despite the uniform administration time. This finding suggests that these agents are capable of acting via different mechanisms or by the differential spatial and temporal dynamics of a common mechanism.<\/jats:p>","DOI":"10.1002\/tera.1420410107","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:11:02Z","timestamp":1118549462000},"page":"61-70","source":"Crossref","is-referenced-by-count":17,"title":["Induction of postaxial forelimb ectrodactyly with anticonvulsant agents in A\/J mice"],"prefix":"10.1002","volume":"41","author":[{"given":"Michael D.","family":"Collins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rochelle","family":"Fradkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"William J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000455547","article-title":"Genetic differences in phenytoin pharmacokinetics: in vivo clearance and in vitro metabolism among inbred strains of mice","volume":"1","author":"Atlas S. 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