{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T22:19:12Z","timestamp":1698185952303},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,6]],"date-time":"2005-06-06T00:00:00Z","timestamp":1118016000000},"content-version":"vor","delay-in-days":5635,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It has been demonstrated that an autosomal recessive gene, <jats:italic>fused pulmonary lobes (fpl)<\/jats:italic>, causes fusion of the right pulmonary lobes with several associated malformations and a high incidence of death in homozygous newborns (Aoyama et al. Teratology 1988; 37:159\u2013166). The aim of the present study was to investigate whether the deaths of <jats:italic>fpl<\/jats:italic>\/<jats:italic>fpl<\/jats:italic> newborns were caused by functional abnormalities of the malformed lung or other associated malformations. Day\u201020 <jats:italic>fpl<\/jats:italic>\/<jats:italic>fpl<\/jats:italic> and <jats:italic>fpl<\/jats:italic>\/ + fetuses were weighed and examined for gross abnormalities. The lungs of selected fetuses were further examined for histological abnormalities. A wide variety of associated external, visceral, and skeletal anomalies as well as relatively lower body weights than those of phenotypically normal <jats:italic>fpl<\/jats:italic>\/ + littermates were observed in the <jats:italic>fpl<\/jats:italic>\/<jats:italic>fpl<\/jats:italic> fetuses. The associated anomalies consisted of hematomas and\/or subcutaneous hemorrhages in the head, truncus and limbs, eyelid anomalies, CNS defects, lobation anomalies of the liver, hypoplasia of the spleen, partial absence of the skull bones, and dorsi\u2010 or ventriflexion of the phalanges of the limbs. Among them, CNS defects and partial absence of the skull bones were considered to be possible causes of newborn deaths. However, the incidence of these malformations was approximately 10% and was lower than the neonatal mortality, which had been estimated to be approximately 50% in the previous study (Aoyama et al. Teratology 1988; 37:159\u2013166). The lungs of <jats:italic>fpl<\/jats:italic>\/<jats:italic>fpl<\/jats:italic> fetuses consistently had hypoplasia of the intermediate lobe and fusion of the right pulmonary lobes. No histological changes suggesting postnatal respiratory insufficiency were found in the lungs of day\u201020 <jats:italic>fpl<\/jats:italic>\/<jats:italic>fpl<\/jats:italic> fetuses, and the cause of newborn death remains unclear.<\/jats:p>","DOI":"10.1002\/tera.1420410112","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:11:02Z","timestamp":1118549462000},"page":"113-122","source":"Crossref","is-referenced-by-count":5,"title":["Congenital malformations in rats with the semilethal mutation <i>fused pulmonary lobes<\/i>"],"prefix":"10.1002","volume":"41","author":[{"given":"Hiroaki","family":"Aoyama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Shirasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(65)80193-7"},{"key":"e_1_2_1_3_1","first-page":"736","article-title":"Derivation of type 1 epithelium from type 2 cells in the developing rat lung","volume":"32","author":"Adamson I. 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