{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T21:56:26Z","timestamp":1770501386119,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T00:00:00Z","timestamp":1118275200000},"content-version":"vor","delay-in-days":5607,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1990,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of 5\u2010azacytidine\u2010induced exencephaly was compared between MT\/HokIdr strain (MT) and Slc:ICR strain (ICR) mice. MT mice have a genetic predisposition for exencephaly, but ICR mice do not. Pregnant mice were given 5\u2010azacytidine (1 mg\/kg to 100 \u03bcg\/kg) injected intraperitoneally on Day 7.5 of gestation (vaginal plug day = Day 0.5), and fetuses were observed for external malformations on Day 18.5 of gestation. One hundred \u03bcg\/kg 5\u2010azacytidine induced exencephaly in MT mice but not in ICR mice, and 1 mg\/kg 5\u2010azacytidine resulted in resorptions in MT mice but caused exencephaly in ICR mice. These results indicated that MT mice had 10\u2010fold more sensitivity to 5\u2010azacytidine than ICR mice. It seems likely that less than effective doses of teratogens for animals without genetic predispositions are still effective in inducing malformations in animals with a genetic predisposition for malformations. When 4\u2010somite\u2010stage embryos of both MT and ICR mice were cultured in rat serum supplemented with 5\u2010azacytidine, 0.02 \u03bcg\/ml 5\u2010azacytidine induced the failure of closure of cephalic neural tube in MT embryos but not in ICR embryos, and 0.2 \u03bcg\/ml 5\u2010azacytidine induced severe growth retardation in MT embryos but in ICR embryos it only induced embryos with smaller heads and fewer somites than in control. These results indicated that MT mouse embryos in culture also had a 10\u2010fold\u2010increased sensitivity to 5\u2010azacytidine compared with ICR mouse embryos, suggesting maternal effects play no significant role in their increased sensitivity to 5\u2010azacytidine.<\/jats:p>","DOI":"10.1002\/tera.1420410204","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:14:09Z","timestamp":1118549649000},"page":"147-154","source":"Crossref","is-referenced-by-count":17,"title":["Comparison of the incidence of 5\u2010azacytidine\u2010induced exencephaly between MT\/HokIdr and Slc:ICR mice"],"prefix":"10.1002","volume":"41","author":[{"given":"Motoko","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420250103"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340206"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.10.3.209"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-8749.1974.tb03442.x","article-title":"Clues to the aetiology of neural tube malformations","volume":"32","author":"Carter C. 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