{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:14:05Z","timestamp":1760577245450},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":5387,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effects of secondary bile acids (lithocholic\u2014LCA, and deoxycholic\u2014DCA) on the in vivo development of rat embryos and fetuses were studied. Daily intraperitoneal injections of 2 ml of 1 mM LCA and of 5 mM DCA during days 6 till 15 of pregnancy resulted in an increase of resorptions among 20 day\u2010old fetuses to 22.8% and 9.9%, respectively, vs. 6.2% in controls. Similar injections on days 12 to 19 resulted in an increase of resorptions to 10.3% after treatment with LCA and to 36% after treatment with DCA. Percent of retarded embryos was similar for both bile acids: 7.7 and 8.7% after injections on days 6\u201315 and 12.3\u201312.5% after injections on days 12\u201319 of gestation. This was accompanied by a significant increase in the wet weight of the placenta of living embryos. Intraamniotic injections of 2 \u03bcl of 1 mM LCA into 10 day\u2010old embryos resulted in 18.5% resorptions (vs. 7.5% in controls), 9.2% malformations, and 3.1% growth retardations observed on day 12 of pregnancy. The rate of resorptions following this treatment increased on day 20 of pregnancy to 71% vs. 16% in controls. No differences were found in the wet weight of 20 day\u2010old living fetuses or their livers and placentas between experimental and control groups following i.p. or intraamniotic injections. In addition, single intrauterine instillation of 0.2 ml of 1 mM LCA 10\u201314 days before mating with normal isogeneic males resulted in 9% of malformations among 12 day\u2010old embryos while malformations were absent in the saline\u2010injected controls. The deleterious effects of secondary bile acids to the embryos were accompanied by damage to the visceral yolk sac. These findings may be significant in relation to the complications previously associated with cholestasis of pregnancy in humans.<\/jats:p>","DOI":"10.1002\/tera.1420420305","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:18:52Z","timestamp":1118549932000},"page":"215-224","source":"Crossref","is-referenced-by-count":18,"title":["Effects of secondary bile acids on the intrauterine development in rats"],"prefix":"10.1002","volume":"42","author":[{"given":"Amazia","family":"Zimber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Zusman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1988.tb10723.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-0898-0_3"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112844"},{"key":"e_1_2_1_5_1","first-page":"259","volume-title":"Pathobiology Annual","author":"Danielsson H.","year":"1981"},{"key":"e_1_2_1_6_1","first-page":"155","volume-title":"Physiology of the Digestive Tract","author":"Davenport H. 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