{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:41:28Z","timestamp":1770964888061,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":5296,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1990,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various well\u2010defined stages during completion of the second meiotic division and early organogenesis of mouse embryos were X\u2010irradiated with doses of 1\u20134 Gy (100\u2013400 rad). The major risk was prenatal mortality with radiation sensitivity changing markedly with dependence on the developmental stage irradiated; in the case of day 1 even within hours. The surviving fetuses did show a significantly enhanced frequency of malformations on day 19 of gestation (mostly gastroschisis and some exencephalies). This was true for all stages between days 1 and 8; only sensitivity again changed considerably. The radiation doses used in this study are markedly higher than doses that can be expected from radiation diagnostics, but exposure is in a range comparable to doses that can occur in radiation therapy (e.g., Morbus Hodgkin).<\/jats:p>","DOI":"10.1002\/tera.1420420609","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T04:27:44Z","timestamp":1118550464000},"page":"643-650","source":"Crossref","is-referenced-by-count":40,"title":["Lethal and teratogenic effects after exposure to X\u2010rays at various times of early murine gestation"],"prefix":"10.1002","volume":"42","author":[{"given":"W.\u2010U.","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Streffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/3572142"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553007314551461"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030590309"},{"key":"e_1_2_1_5_1","first-page":"272","article-title":"Developmental malformations produced by radiation","volume":"69","author":"Hicks S. P.","year":"1953","journal-title":"AJR Am. J. Roentgenol."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-55-653-321"},{"key":"e_1_2_1_7_1","first-page":"277","article-title":"A comparison of the cell kinetics of pre\u2010implantation mouse embryos from two different mouse strains","volume":"16","author":"Molls M.","year":"1983","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01221226"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/3571800"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370609"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553008914550091"},{"key":"e_1_2_1_12_1","first-page":"993","article-title":"Effects of preimplantation low\u2010dose radiation on rat embryos","volume":"45","author":"Roux C.","year":"1983","journal-title":"Health Phys."},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-195907000-00009"},{"key":"e_1_2_1_14_1","first-page":"125","article-title":"Fractionated X\u2010irradiation of the mammalian embryo and congenital anomalies","volume":"84","author":"Rugh R.","year":"1960","journal-title":"AJR Am. J. Roentgenol."},{"key":"e_1_2_1_15_1","first-page":"521","article-title":"The effects of radiation on the preimplantation stages of the mouse embryo","volume":"108","author":"Russell L. B.","year":"1950","journal-title":"Anat. Rec."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030430407"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/3574876"},{"key":"e_1_2_1_18_1","first-page":"135","article-title":"Kinetics of cell proliferation in the preimplanted mouse embryo in vivo and in vitro","volume":"13","author":"Streffer C.","year":"1980","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_19_1","volume-title":"Report of the United Nations Scientific Committee on the Effects of Atomic Radiation: Sources and Effects of Ionizing Radiation","author":"UNSCEAR","year":"1977"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420420609","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420420609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T09:45:45Z","timestamp":1697967945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420420609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,12]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1990,12]]}},"alternative-id":["10.1002\/tera.1420420609"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420420609","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,12]]}}}