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In the present investigations, the development of the limbs from the time of treatment until the appearance of the defect on day 14 were studied at 12\u2010 to 24\u2010hr intervals with histological and vital staining technics. A diffuse cytotoxicity in the central proximal mesoderm was noted with a safranin\u2013toluidine blue stain 12 h after treatment which then peaked 24 hr after treatment. Treated limbs stained with Nile blue sulfate showed a significant increase of necrotic mesodermal cells in the foyer preaxial primaire, foyer marginal I and foyer marginal V when compared to the respective control group. The treated postaxial ectoderm was more hyperplastic than was the control ectoderm on day 12. The treated group developed a squarish bulge on the postaxial boundary of the fifth digital ray on day 14 that was larger than those of the controls. Most of the controls had bulges that were completely necrotic. The treated group also had some completely necrotic bulges but a large number of the treated fetuses had bulges characterized as being less than 60% necrotic.<\/jats:p>","DOI":"10.1002\/tera.1420430102","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:46:43Z","timestamp":1118515603000},"page":"1-9","source":"Crossref","is-referenced-by-count":7,"title":["Morphogenesis of retinoic acid\u2010induced postaxial polydactyly in mice"],"prefix":"10.1002","volume":"43","author":[{"given":"S. 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