{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:14:22Z","timestamp":1764688462626},"reference-count":185,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":5023,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1991,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this paper was to illustrate the spectrum of possible limb malformations in mammals resulting from drug exposure. A bibliography of 171 papers from 20 journals was generated from which pertinent data (drug used, limb defects reported, predominant defect location) were tabulated. These data should provide a basis for predictions about types of defects that might be expected in further studies and for judging postulated drug\u2010induced human limb defects. However, direct extrapolation to humans is inappropriate. The following trends were observed: 1) Distal limb defects (autopod) are almost twice as common as proximal limb defects (stylopod and zygopod). 2) Ectrodactyly is the single most common type of limb defect, accounting for over half of the autopod defects. 3) Ectrodactyly is almost twice as common in the hindlimb as in the forelimb. 4) Postaxial ectrodactyly is over twice as common as preaxial ectrodactyly in the forelimb, but preaxial ectrodactyly is four times more common in the hindlimbs. 5) Polydactyly occurs with approximately equal frequency in forelimbs and hindlimbs, and preaxial polydactyly is most common in both fore and hindlimbs. 6) Polymelia (supernumerary limbs) occurred in one case, and may have been a spurious result. 7) Either transverse hemimelia is greatly underreported in teratology studies or it essentially does not occur. We have concluded that, at least in some cases, acetazolamide, adenine, 1,7\u2010dimethylxanthine, and xanthine derivative aminophylline, retinoic acid, acetoxy\u2010methyl\u2010methylnitrosamine, aspirin, and cadmium can all cause unilateral defects.<\/jats:p>","DOI":"10.1002\/tera.1420440310","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T18:51:00Z","timestamp":1118515860000},"page":"335-354","source":"Crossref","is-referenced-by-count":25,"title":["Review of drug\u2010induced limb defects in mammals"],"prefix":"10.1002","volume":"44","author":[{"given":"Duane D.","family":"Sanders","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trent D.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340312"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070304"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420240207"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020208"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070110"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420130114"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420130205"},{"key":"e_1_2_1_9_1","first-page":"1488","article-title":"Ectrodactylie provoqu\u00e9e par la caf\u00e9ine chez les rongeurs: R\u00f4le des facteurs sp\u00e9cifiques et g\u00e9n\u00e9tiques","volume":"164","author":"Bertrand M.","year":"1970","journal-title":"C. R. Soc. Biol. (Paris)"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420110104"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420110105"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370411"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333418"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420380308"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420200211"},{"key":"e_1_2_1_16_1","first-page":"505","volume-title":"Limb Development and Deformity: Problems of Evaluation and Rehabilitation","author":"Burtch R. L.","year":"1969"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420100304"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020104"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010205"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310107"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001060202"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401640313"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050313"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-86-21207"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010309"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190104"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420240104"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150211"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.145.3631.501"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420090107"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190203"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420110114"},{"key":"e_1_2_1_33_1","first-page":"231","article-title":"Patterns of deformities in congenital anomalies of the upper limb and their relation to classification","author":"Entin M. A.","year":"1977","journal-title":"Birth Defects"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150109"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170117"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350203"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140202"},{"key":"e_1_2_1_38_1","volume-title":"The Care of Congenital Hand Anomalies","author":"Flatt A. E.","year":"1977"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420060103"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420110102"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020409"},{"key":"e_1_2_1_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150206"},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420030404"},{"key":"e_1_2_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280106"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.2535\/ofaj1936.46.4_167"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.2535\/ofaj1936.49.2-3_75"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420100210"},{"key":"e_1_2_1_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420030310"},{"key":"e_1_2_1_49_1","first-page":"219","article-title":"Les anomalies digitales: Manifestations t\u00e9ratog\u00e9niques des d\u00e9riv\u00e9s xanthiques chez le rat","volume":"172","author":"Georges A.","year":"1968","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010406"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040205"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350106"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420080205"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040304"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280307"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350306"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420090112"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070206"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180314"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80759-3"},{"key":"e_1_2_1_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170309"},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370407"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420200212"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420170108"},{"key":"e_1_2_1_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420130103"},{"key":"e_1_2_1_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420060216"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420110312"},{"key":"e_1_2_1_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140207"},{"key":"e_1_2_1_69_1","first-page":"169","article-title":"Symbrachydactyly: Pathogenesis of 5\u2010fluorouracil induced model in mice","volume":"29","author":"Imagawa S.","year":"1980","journal-title":"Hiroshima J. Med. Sci."},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180213"},{"key":"e_1_2_1_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190310"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420080106"},{"key":"e_1_2_1_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010207"},{"key":"e_1_2_1_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230311"},{"key":"e_1_2_1_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020307"},{"key":"e_1_2_1_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150110"},{"key":"e_1_2_1_77_1","first-page":"59","article-title":"Morphogenesis of 5\u2010fluorouracil\u2010induced polydactylism in mice.\u2010Epithelial\u2010mesenchymal interactions in the formation of polydactylism","volume":"21","author":"Kameyama Y.","year":"1974","journal-title":"Ann. Rep. Res. Ins. Env. Med. Nagoya U."},{"key":"e_1_2_1_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300109"},{"key":"e_1_2_1_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420110108"},{"key":"e_1_2_1_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140104"},{"key":"e_1_2_1_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420240204"},{"key":"e_1_2_1_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040104"},{"key":"e_1_2_1_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230106"},{"key":"e_1_2_1_84_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402160111"},{"key":"e_1_2_1_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050304"},{"key":"e_1_2_1_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420090103"},{"key":"e_1_2_1_87_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180105"},{"key":"e_1_2_1_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230209"},{"key":"e_1_2_1_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070310"},{"key":"e_1_2_1_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(77)90310-4"},{"key":"e_1_2_1_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420360110"},{"key":"e_1_2_1_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180111"},{"key":"e_1_2_1_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcm.1770040407"},{"key":"e_1_2_1_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420290314"},{"key":"e_1_2_1_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350211"},{"key":"e_1_2_1_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00304671"},{"key":"e_1_2_1_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420140208"},{"key":"e_1_2_1_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040113"},{"key":"e_1_2_1_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.149.3681.306-a"},{"key":"e_1_2_1_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190213"},{"key":"e_1_2_1_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190202"},{"key":"e_1_2_1_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120311"},{"key":"e_1_2_1_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150311"},{"key":"e_1_2_1_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300213"},{"key":"e_1_2_1_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420210315"},{"key":"e_1_2_1_106_1","first-page":"762","article-title":"Obtentio de malformations des membres par la 6\u2010mercaptopurine chez trois esp\u00e8ces: lapin, rat et souris","volume":"161","author":"Mercier\u2010Parot L.","year":"1967","journal-title":"C. R. Soc. Biol. (Paris)"},{"key":"e_1_2_1_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420290212"},{"key":"e_1_2_1_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420250109"},{"key":"e_1_2_1_109_1","first-page":"167","article-title":"\u00c9tude morphog\u00e9n\u00e9tique de las syndactylie postaxiale provoqu\u00e9e chez le rat par l'hadacidine. I. Analyse des anomalies chez l'adulte, le foetus a terme et les embryons","volume":"80","author":"Milaire J.","year":"1969","journal-title":"Arch. Biol. (Liege)"},{"key":"e_1_2_1_110_1","first-page":"207","article-title":"A review of experimental and descriptive data supporting current concepts on the mechanisms of limb teratogenesis","volume":"99","author":"Milaire J.","year":"1988","journal-title":"Arch. Biol. (Bruxelles)"},{"key":"e_1_2_1_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420330310"},{"key":"e_1_2_1_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150307"},{"key":"e_1_2_1_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280214"},{"key":"e_1_2_1_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420160106"},{"key":"e_1_2_1_115_1","first-page":"211","article-title":"Effects of 5\u2010fluorouracil and cytosine arabinoside on the manifestation of digital malformations in Pdn mice","volume":"23","author":"Naruse I.","year":"1983","journal-title":"Cong. Anom."},{"key":"e_1_2_1_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340308"},{"key":"e_1_2_1_117_1","first-page":"109","article-title":"Correlations among preaxial polydactyly, tibial hemimelia and triphalangia induced by bromodeoxyuridine in mice","volume":"30","author":"Naruse I.","year":"1986","journal-title":"Environ. Med."},{"key":"e_1_2_1_118_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.127.3303.877"},{"key":"e_1_2_1_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040405"},{"key":"e_1_2_1_120_1","first-page":"14","article-title":"The nomenclature and classification of limb anomalies","author":"O'Rahilly R.","year":"1969","journal-title":"Birth Defects"},{"key":"e_1_2_1_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180110"},{"key":"e_1_2_1_122_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420090104"},{"key":"e_1_2_1_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420380309"},{"key":"e_1_2_1_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340305"},{"key":"e_1_2_1_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340306"},{"key":"e_1_2_1_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370103"},{"key":"e_1_2_1_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120207"},{"key":"e_1_2_1_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420190305"},{"key":"e_1_2_1_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040103"},{"key":"e_1_2_1_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070302"},{"key":"e_1_2_1_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120304"},{"key":"e_1_2_1_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420250113"},{"key":"e_1_2_1_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320105"},{"key":"e_1_2_1_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350107"},{"key":"e_1_2_1_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120309"},{"key":"e_1_2_1_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420120110"},{"key":"e_1_2_1_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420080211"},{"key":"e_1_2_1_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310103"},{"key":"e_1_2_1_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420150304"},{"key":"e_1_2_1_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050213"},{"key":"e_1_2_1_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420030308"},{"key":"e_1_2_1_142_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230313"},{"key":"e_1_2_1_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280314"},{"key":"e_1_2_1_144_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1242\/dev.99.1.127","article-title":"Ventral duplication of the autopod: chemical induction by methoxyacetic acid in rat embryos","volume":"99","author":"Scott W. J.","year":"1987","journal-title":"Development"},{"key":"e_1_2_1_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420210303"},{"key":"e_1_2_1_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420050115"},{"key":"e_1_2_1_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420100305"},{"key":"e_1_2_1_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420240307"},{"key":"e_1_2_1_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320308"},{"key":"e_1_2_1_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420090206"},{"key":"e_1_2_1_151_1","volume-title":"Teratology of the Limbs","author":"Skalko R. G.","year":"1980"},{"key":"e_1_2_1_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420040112"},{"key":"e_1_2_1_153_1","first-page":"323","article-title":"The effect of 5\u2010bromodeoxyuridine on mouse limb development: A scanning electron microscope study","volume":"3","author":"Skalko R. G.","year":"1977","journal-title":"Acta Embryol. Morphol. Exp."},{"key":"e_1_2_1_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320110"},{"key":"e_1_2_1_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310311"},{"key":"e_1_2_1_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420070215"},{"key":"e_1_2_1_157_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420260111"},{"key":"e_1_2_1_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420370602"},{"key":"e_1_2_1_159_1","volume-title":"Limb Development and Deformity: Problems of Evaluation and Rehabilitation","author":"Swinyard C. A.","year":"1969"},{"key":"e_1_2_1_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180104"},{"key":"e_1_2_1_161_1","first-page":"335","article-title":"Mitigation of caffeine\u2010induced properties","volume":"23","author":"Terada M.","year":"1975","journal-title":"Teratology"},{"key":"e_1_2_1_162_1","first-page":"241","article-title":"Effects of ethylenethiourea upon developing brain and limb buds in the rat","volume":"18","author":"Teramoto S.","year":"1978","journal-title":"Cong. Anom."},{"key":"e_1_2_1_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420230308"},{"key":"e_1_2_1_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(78)90017-6"},{"key":"e_1_2_1_165_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310213"},{"key":"e_1_2_1_166_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340208"},{"key":"e_1_2_1_167_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270214"},{"key":"e_1_2_1_168_1","first-page":"579","article-title":"Concerning the morphogenesis of thalidomide dysmelia in rabbits","volume":"48","author":"Vickers T. H.","year":"1967","journal-title":"Br. J. Exp. Pathol."},{"key":"e_1_2_1_169_1","first-page":"5","article-title":"Acetazolamide dysmelia in rats","volume":"53","author":"Vickers T. H.","year":"1972","journal-title":"Br. J. Exp. Pathol."},{"key":"e_1_2_1_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420130310"},{"key":"e_1_2_1_171_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420350205"},{"key":"e_1_2_1_172_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300112"},{"key":"e_1_2_1_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300206"},{"key":"e_1_2_1_174_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300207"},{"key":"e_1_2_1_175_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420270211"},{"key":"e_1_2_1_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420240103"},{"key":"e_1_2_1_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420020108"},{"key":"e_1_2_1_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180204"},{"key":"e_1_2_1_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420010107"},{"key":"e_1_2_1_180_1","first-page":"125","article-title":"Incorporation of 5\u2010bromo\u20102\u2032\u2010deoxyuridine into mesenchymal limb\u2010bud cells destined to die: relationship to polydactyly induction in rats","volume":"72","author":"Wise L. D.","year":"1982","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420210316"},{"key":"e_1_2_1_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420240107"},{"key":"e_1_2_1_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340106"},{"key":"e_1_2_1_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420310206"},{"key":"e_1_2_1_185_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340307"},{"key":"e_1_2_1_186_1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0030-5898(20)30197-8","article-title":"Foot deformities","volume":"7","author":"Zimbler S.","year":"1976","journal-title":"Orthop. Clin. North Am."}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420440310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420440310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:21:24Z","timestamp":1698024084000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420440310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,9]]},"references-count":185,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,9]]}},"alternative-id":["10.1002\/tera.1420440310"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420440310","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,9]]}}}