{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:00:55Z","timestamp":1761764455088},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":4932,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1991,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The authors have performed an international case\u2010control study on the significance of exogenous hormones for the origin of hypospadias (K\u00e4ll\u00e9n et al., 1991a, b). Using data from this study on 846 infants with isolated hypospadias and equally many controls (next male infant born in the same hospital as the case), variables that might indicate an increased rate of fertility problems in couples who had a boy with hypospadias were studied. Cases had slightly fewer previous pregnancies, there was practically no difference in the rate of previous induced abortions, and no demonstrable difference in menstrual history. Infertility periods of at least 6 months were more likely among cases than controls but the difference did not reach statistical significance in a two\u2010tailed test. There was no demonstrable difference in the time to conceive between cases and controls. The difficulties of directly studying subfertility problems are stressed.<\/jats:p>","DOI":"10.1002\/tera.1420440605","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:47:17Z","timestamp":1118504837000},"page":"629-634","source":"Crossref","is-referenced-by-count":18,"title":["Parental fertility and infant hypospadias: An international case\u2010control study"],"prefix":"10.1002","volume":"44","author":[{"given":"Bengt","family":"K\u00e4ll\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo E.","family":"Castilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Kringelbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A. L.","family":"Lancaster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Mart\u00ednez\u2010Fr\u00edas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaolo","family":"Mastroiacovo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osvaldo","family":"Mutchinick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Robert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114417"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.23.4.333"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91185-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420410207"},{"key":"e_1_2_1_6_1","volume-title":"Aetiological Studies of Isolated Common Congenital Abnormalities in Hungary","author":"Czeizel A.","year":"1984"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320210108"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90005-P"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1986.tb14935.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","unstructured":"K\u00e4ll\u00e9n B. M. L. Mart\u00ednez\u2010Fr\u00edas E. E.Castilla E.Robert P. A. L.Lancaster M.Kringelbach O.Mutchinick andP.Mastroiacovo(1991a)Hormone therapy during pregnancy and isolated hypospadias. An international case\u2010control study (in press).","DOI":"10.1002\/tera.1420440605"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(91)90117-X"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1982.tb09577.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1542\/peds.63.5.788","article-title":"Inheritance of uncomplicated hypospadias","volume":"63","author":"Page L. A.","year":"1979","journal-title":"Pediatrics"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420280109"},{"key":"e_1_2_1_15_1","first-page":"394","article-title":"The risk of infertility and delayed conception associated with exposure in the Danish work\u2010place","volume":"25","author":"Rachootin P.","year":"1983","journal-title":"J. Occup. Med."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5856.768"},{"key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0022-5347(17)56527-1","article-title":"Developmental anomalies associated with hypospadias","volume":"122","author":"Shima H.","year":"1979","journal-title":"J. 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