{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:57:06Z","timestamp":1760345826932},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":4870,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>N,N\u2032\u2010bis(dichloroacetyl)\u20101,8\u2010octamethylenediamine(bis\u2010diamine) (100 \u03bcg) dissolved in dimethylsulfoxide (DMSO) was administered to early developing chick embryos (Hamburger\u2010Hamilton stage 9\u201021) in order to clarify the teratogenic effects on the cardiovascular system and to determine whether bis\u2010diamine interferes with the migration of neural crest cells.<\/jats:p><jats:p>Of 346 cases, 154 (44.5%) survived. The incidence of cardiovascular anomalies was 149 out of 154 cases (96.8%). Infundibular ventricular septal defect, double outlet right ventricle, and persistent truncus arteriosus were the primary cardiac anomalies observed in this study. A high percentage of these anomalies were accompanied by hypoplasia of the right 6th aortic arch artery and persistent left 4th aortic arch artery. Particularly, administration of bis\u2010diamine to chick embryos at stage 13 resulted in a high incidence of persistent truncus arteriosus (64.3%).<\/jats:p><jats:p>Bis\u2010diamine has been suspected to inhibiting the migration of neural crest cells. However, neural crest cells were observed in the tunica media of the great arteries and the truncal valves of persistent truncus arteriosus produced by bis\u2010diamine in chimeric embryos at stage 13. Morphological changes such as cell death were not observed.<\/jats:p>","DOI":"10.1002\/tera.1420450209","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:49:56Z","timestamp":1118504996000},"page":"155-162","source":"Crossref","is-referenced-by-count":8,"title":["Cardiovascular anomalies in chick embryos produced by bis\u2010diamine in dimethylsulfoxide"],"prefix":"10.1002","volume":"45","author":[{"given":"Takahiro","family":"Okishima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Takamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shozo","family":"Ohdo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6606851"},{"key":"e_1_2_1_3_1","first-page":"237","volume-title":"Congenital Heart Disease: Causes and Processes","author":"Chon Y.","year":"1984"},{"key":"e_1_2_1_4_1","first-page":"637","article-title":"Cardiovascular anomalies induced by bisdiamine in chicks","volume":"91","author":"Chon Y.","year":"1987","journal-title":"Nippon Shounikagakkai Zasshi"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-2305-1_1"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(84)90447-8"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(60)90088-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050880104"},{"key":"e_1_2_1_9_1","first-page":"267","article-title":"Experimental study on pathogenesis and morphogenesis of congenital heart defects. Conotruncal abnormality produced by bis(dichloroacetyl)diamine","volume":"23","author":"Hayakawa K.","year":"1983","journal-title":"Cong. Anom."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(61)90002-3"},{"key":"e_1_2_1_11_1","first-page":"223","volume-title":"Congenital Heart Disease: Causes and Processes","author":"Ikeda T.","year":"1984"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6844926"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198703000-00001"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420300108"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420360307"},{"key":"e_1_2_1_16_1","first-page":"751","article-title":"Morphological studies on the persistent truncus arteriosus, hypoplasia or aplasia of the pulmonary trunk and aortic arch anomalies induced by bis\u2010diamine in rats","volume":"31","author":"Lee J. Y.","year":"1983","journal-title":"Hiroshima Med. J."},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420390310"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.1.255"},{"key":"e_1_2_1_19_1","volume-title":"Congenital Anomalies of the Heart","author":"Okamoto N.","year":"1980"},{"key":"e_1_2_1_20_1","first-page":"199","volume-title":"Congenital Heart Disease: Causes and Processes","author":"Okamoto N.","year":"1984"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1984.tb00365.x"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.1985.tb00632.x"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(74)90117-3"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420180104"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90256-0"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420450209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420450209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T09:32:10Z","timestamp":1698053530000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420450209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1002\/tera.1420450209"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420450209","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}