{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:34:34Z","timestamp":1758926074747},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":4810,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1992,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Murine trisomy 16 (mts16) placentas and fetuses, 17\u2010day gestation age, were examined histologically and by magnetic resonance imaging at 9.4 T and compared with control littermate tissues. Placentas were studied by immunohistochemical methods, at 15\u2010days gestational age, for expression of the major histocompatibility complex (MHC) class I H\u20102K<jats:sup>k<\/jats:sup> cell surface marker. Immunohistochemical studies revealed a markedly increased expression of the MHC marker H\u20102K<jats:sup>k<\/jats:sup> on cells in the labyrinth of the placenta of mts16. There were differences between the magnetic resonance (MR) images of the trisomic and normal placentas, which may be correlated with the increased expression of H\u20102K<jats:sup>k<\/jats:sup> in the mts16 placental labyrinth. The decidual and labyrinthine components of the normal placentas showed similar high signal intensities (SI) while in trisomic placentas a marked high SI was characteristic only of the decidual region on proton spin density images. The MRI also revealed a smaller cerebellum in the ts16 fetuses. The potential effects of the compromised structure of the placental labyrinth and the overexpression of the H\u20102K<jats:sup>k<\/jats:sup> marker on the mts16 neural and placental dysgenesis are discussed.<\/jats:p>","DOI":"10.1002\/tera.1420450409","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:50:36Z","timestamp":1118505036000},"page":"383-391","source":"Crossref","is-referenced-by-count":7,"title":["Correlation of increased levels of class I MHC H\u20102K<sup>k<\/sup> in the placenta of murine trisomy 16 conceptuses with structural abnormalities revealed by magnetic resonance microscopy"],"prefix":"10.1002","volume":"45","author":[{"given":"Steven","family":"Kornguth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Bersu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Markley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420400514"},{"key":"e_1_2_1_3_1","first-page":"183","volume-title":"Trisomy 21. 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