{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:46:48Z","timestamp":1771548408889,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":4749,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1992,6]]},"abstract":"Abstract<\/jats:title>A theoretical basis for the embyology of conjoined twins was formulated from clinical experience with ten cases and extensive review of pertinent embryologic and clinical literature, including over 500 cases. Regarding the age old question of fusion or fission<\/jats:italic>, it is concluded that there is no known embryologic process by which conjoined twins can be formed by fission but firm evidence to support fusion in all cases. Whether the fusion occurs between embryos on one embryonic disc or on two is of no consequence since they are all monovular. Intact ectoderm will not fuse to intact ectoderm, and all seven types of conjoined twins are explained by seven possible sites of union in the early embryo. One new term is proposed: parapagus<\/jats:italic>, from the Greek para<\/jats:italic>, meaning \u201cside,\u201d combined with pagus<\/jats:italic>, meaning \u201cfixed\u201d; this is the group formerly called dicephalus or diprosopos. These anterolaterally united parapagus twins must result from two nearly parallel notochords in close proximity; craniopagi and pygopagi from fusion at the cranial and caudal neuropores, respectively; cephalopagi and ischiopagi from union at the pharyngeal and cloacal membranes, respectively; thoracopagi from merging of the cardiac anlage; and omphalopagi from fusion of the umbilicus or of the edges of two embryonic discs in any area not including the above sites. Parasitic twins result from embryonic death of one twin, leaving various portions of the body vascularized by the surviving autosite.<\/jats:p>The rarity of cases (2) not easily explained by the above theories, and the nearly 6% of twins with two umbilical cords arising from the placenta would seem to support these conclusions.<\/jats:p>Should one wish to learn the methods of a conjurer, he might vainly watch the latter's customary repertoire, and, so long as everything went smoothly, might never obtain a clue to the mysterious performance, baffled by the precision of the manipulations and the complexity of the apparatus; if, however, a single error were made in any part or if a single deviation from the customary method should force the manipulator along an unaccustomed path, it would give the investigator an opportunity to obtain a part or the whole of the secret. Thus \u2026 it seems likely that through the study of the abnormal or unusual some insight may be obtained into that mystery of mysteries, the development of an organism \u2026 especially \u2026 where the abnormalities \u2026 are due to some modification in the germ itself, leading the organism to develop in accordance with laws as definite and natural, though not as usual, as those governing normal development (Wilder, '08). \u00a9 1992 Wiley \u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tera.1420450604","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:51:43Z","timestamp":1118505103000},"page":"591-602","source":"Crossref","is-referenced-by-count":135,"title":["Conjoined twins: Theoretical embryologic basis"],"prefix":"10.1002","volume":"45","author":[{"given":"Rowena","family":"Spencer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1985.4.9.485"},{"key":"e_1_2_1_3_1","first-page":"95","volume-title":"Developmental Anatomy","author":"Arey L. B.","year":"1965"},{"key":"e_1_2_1_4_1","first-page":"632","volume-title":"Manual of Antenatal Hygiene: The Embryo","author":"Ballantyne J. W.","year":"1905"},{"key":"e_1_2_1_5_1","unstructured":"Benirschke K.(1991) Personal Communication."},{"key":"e_1_2_1_6_1","first-page":"34","volume-title":"Biokinetics and Biodynamics of Human Differentiation: Principles and Applications","author":"Blechschmidt E.","year":"1978"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.29.2.268"},{"key":"e_1_2_1_8_1","unstructured":"Fisher G. J.(1865\u201068)Diploteratology. Tr. Med. Soc. State N.Y. 232\u2013268 1865 207\u2013296 1866 396\u2013430 1867 276\u2013306 1868."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(68)90107-3"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513818909037736"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1969.10666855"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02080957"},{"key":"e_1_2_1_13_1","first-page":"304","article-title":"A case report of a posterior incomplete double monster with duplication of the spine, colon, bladder, and urethra in a male newborn baby","volume":"4","author":"Montagnini C. A.","year":"1967","journal-title":"Z. Kinderchir."},{"key":"e_1_2_1_14_1","first-page":"17","article-title":"Twins, conjoined Twins, and cardiac defects","volume":"132","author":"Noonan J. A.","year":"1978","journal-title":"Am. J. Dis. Child"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(69)90498-9"},{"key":"e_1_2_1_16_1","first-page":"223","volume-title":"Pathology of The Fetus and The Infant","author":"Potter E.","year":"1975"},{"key":"e_1_2_1_17_1","first-page":"111","article-title":"Unusual xiphopagus conjoined twins","volume":"31","author":"Rathore A. H.","year":"1981","journal-title":"J.A.M.A."},{"key":"e_1_2_1_18_1","first-page":"175","volume-title":"Die Morphologie der Misbildungen des Menschen und der Tiere: Die Doppelbildungen","author":"Schwalbe E.","year":"1907"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(74)80019-9"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420320202"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.1988.3.1.19"},{"key":"e_1_2_1_22_1","first-page":"827","article-title":"Surgical separation of Siamese twins: Case report","volume":"39","author":"Spencer R.","year":"1956","journal-title":"Surgery"},{"key":"e_1_2_1_23_1","unstructured":"Spencer R.Collective Review of Conjoined Twins in preparation."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000280202"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02079775"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000080113"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420450604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420450604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T10:59:31Z","timestamp":1698058771000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420450604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,6]]}},"alternative-id":["10.1002\/tera.1420450604"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420450604","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}