{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:21:54Z","timestamp":1791296514014,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":4627,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During craniofacial development in the mouse embryo (days 9\u201312 of gestation; plug day = day 1), transient expression of serotonin (5\u2010HT) uptake in epithelial structures of this region correlates with critical morphogenetic events (Lauder et al., '88; Shuey, '91; Shuey et al., '89, '92). The purpose of the present investigation was to assess the possible functional significance of these uptake sites by examination of patterns of dysmorphology following exposure of embryos to selective 5\u2010HT uptake inhibitors. Exposure of mouse embryos in whole embryo culture to sertraline, at a concentration (10 \u03bcM) which produced no evidence of general embryotoxicity, caused craniofacial malformations consistent with direct action at 5\u2010HT uptake sites. Two other 5\u2010HT uptake inhibitors, fluoxetine and amitriptyline, produced similar defects. The critical period of sertraline exposure occurred on days 10\u201311. The observed craniofacial defects were associated with decreased proliferation and extensive cell death in mesenchyme located 5\u20136 cell layers deep from the overlying epithelium. In contrast, the subepithelial mesenchymal layers showed normal or elevated levels of proliferation. From these results it appears that inhibition of 5\u2010HT uptake into craniofacial epithelia may produce developmental defects by interference with serotonergic regulation of epithelial\u2013mesenchymal interactions important for normal craniofacial morphogenesis. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tera.1420460407","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:20:52Z","timestamp":1118535652000},"page":"367-378","source":"Crossref","is-referenced-by-count":124,"title":["Serotonin as a regulator of craniofacial morphogenesis: Site specific malformations following exposure to serotonin uptake inhibitors"],"prefix":"10.1002","volume":"46","author":[{"given":"Dana L.","family":"Shuey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Sadler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean M.","family":"Lauder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"167","article-title":"Relative growth rates of maxillary mesenchyme in the chick embryo","volume":"8","author":"Bailey L. 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