{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:47:50Z","timestamp":1760906870327},"reference-count":8,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":4566,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1992,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe an epidemiological and clinical study of Clinical Anopthalmia in a population of consecutive live and stillborns enrolled in a hospital based registry of congenital malformations in Northeast Italy during the period from 1981 to 1989; 22 cases were detected among 368,256 births yielding a birth prevalence of 0.60 per 10,000 (95% CI 0.34\u20130.84); 20 cases were associated with at least one other major malformation. Malformation syndrome, association, or sequence was diagnosed in 13, while a non\u2010recognizable multiple defect pattern was observed in 7\/20 (35%). A chromosomal anomaly was present in eight syndromic cases. No significant trend over time, nor space or time clusters, were detected. As most CAn cases are associated with other anomalies recognizable by ultrasound, a decreasing trend in its prevalence at birth is expected in the future. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tera.1420460604","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:53:34Z","timestamp":1118505214000},"page":"551-553","source":"Crossref","is-referenced-by-count":39,"title":["Clinical anophthalmia: An epidemiological study in Northeast Italy based on 368,256 consecutive births"],"prefix":"10.1002","volume":"46","author":[{"given":"Maurizio","family":"Clementi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licia","family":"Turolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Mammi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romano","family":"Tenconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00271183"},{"key":"e_1_2_1_3_1","volume-title":"System of Ophthalmology","author":"Duke\u2010Elder S","year":"1964"},{"key":"e_1_2_1_4_1","unstructured":"Surveillance of congenital anomalies1980\u20131988. M. F.Lechat ed. EUROCAT Report (1991) pp.4:62. M. F.Lechat ed. Eurocat Guide 1.1 (1990) pp.1\u201359."},{"key":"e_1_2_1_5_1","first-page":"237","article-title":"Diagnostic antenatal de certaines maladies hereditaires cecitantes","volume":"4","author":"Michel Award A.","year":"1990","journal-title":"Ophthalmologie"},{"key":"e_1_2_1_6_1","first-page":"415","volume-title":"System of Ophthalmology"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90075-X"},{"key":"e_1_2_1_8_1","unstructured":"Tenconi R. (1987) Registration of congenital anomalies in North East Italy. Appendix IV. In:Surveillance of Congenital Anomalies Years 1980\u20131984. P. De Wals and M. F. Lechat eds. Eurocat Report 1987 pp.249\u2013254."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816818709028526"}],"container-title":["Teratology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Ftera.1420460604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/tera.1420460604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T20:04:42Z","timestamp":1698091482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/tera.1420460604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,12]]}},"alternative-id":["10.1002\/tera.1420460604"],"URL":"https:\/\/doi.org\/10.1002\/tera.1420460604","archive":["Portico"],"relation":{},"ISSN":["0040-3709","1096-9926"],"issn-type":[{"value":"0040-3709","type":"print"},{"value":"1096-9926","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12]]}}}