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When compared to growth in control embryos, a significant dose\u2010dependent decrease in crown\u2010rump lengths, somite numbers, and yolk sac diameters was observed. There was also a significant increase in overall dysmorphology, including eye, branchial arch, and heart anomalies, and an absence of forelimb buds. The neural tube was especially vulnerable and had frequently failed to close. Cellular and ultrastructural examination revealed extensive cell death in the neuroepithelium, with a lesser effect on the mesenchymal cells. Large condensed blebs projected into the ventricular lumen, and cell membranes as well as the basal lamina were severely disrupted, with all cytoplasmic organelles affected in dying cells. It is likely that the extensive cell necrosis and blebbing in the developing neuroepithelium at the site of neural tube fusion may be involved in failed neurulation, while necrosis at other sites in the cranial neuroepithelium may be linked with previously reported intellectual and behavioural abnormalities. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tera.1420480204","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T15:57:37Z","timestamp":1118505457000},"page":"105-114","source":"Crossref","is-referenced-by-count":17,"title":["The Teratogenic effects of salicylic acid on the developing nervous system in rats in vitro"],"prefix":"10.1002","volume":"48","author":[{"given":"Marion A.","family":"Joschko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivor E.","family":"Dreosti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram S.","family":"Tulsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Generalised Linear Interactive Modelling","author":"Baker R. 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