{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:47:12Z","timestamp":1789390032730,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":3655,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Teratology"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Path (Ph)<\/jats:italic> mice, whose platelet\u2010derived growth factor receptor alpha subunit (\u03b1PDGFR) gene has been deleted, have been used to elucidate requirements for \u03b1PDGFR for normal murine development. In this report we evaluate the role of \u03b1PDGFR in cardiovascular development by using in situ hybridization to follow the changing pattern of \u03b1PDGFR expression in cardiovascular tissues after embryonic day 13, and comparing this pattern with the pattern of cardiovascular defects observed in homozygous <jats:italic>Ph<\/jats:italic> mutants. Both mesodermally derived and neural crest\u2010derived components of the cardiovascular system are severely dysmorphic in <jats:italic>Ph\/Ph<\/jats:italic> embryos and those structures most severely affected are those that normally express \u03b1PDGFR mRNA at the highest levels and for the longest duration. <jats:italic>Ph\/Ph<\/jats:italic> vessels appear to be lined with a normal endothelium, but contain a reduced number of smooth muscle cells and are fragile during processing for histology. The myocardium is thin, the heart is small and dysmorphic, the valves are malformed, and the interventricular and interatrial septa of the heart are defective. In the outflow tract, the spectrum of defects includes both persistent truncus arteriosus and double outlet right ventricle. This pattern of abnormalities is consistent with the hypothesis that deletion of \u03b1PDGFR results in a functional ablation of cranial neural crest cells, and that mesodermally derived components of the vascular system also require \u03b1PDGFR. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tera.1420510602","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:09:25Z","timestamp":1118506165000},"page":"351-366","source":"Crossref","is-referenced-by-count":88,"title":["Platelet\u2010derived growth factor receptor alpha subunit deleted <i>Patch<\/i> mouse exhibits severe cardiovascular dysmorphogenesis"],"prefix":"10.1002","volume":"51","author":[{"given":"Gina C.","family":"Schatteman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Tim","family":"Motley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Effmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Bowen\u2010Pope","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6606851"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(91)90316-U"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420340114"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00338048"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300000094"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092340215"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(83)90100-8"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6844926"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092130112"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.3.1047"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.16.1875"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(90)90181-H"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.115.1.133"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.75.1.255"},{"key":"e_1_2_1_16_1","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1242\/dev.115.4.1045","article-title":"Platelet\u2010derived growth factor\u2010A and its receptor are expressed in separate, but adjacent cell layers of the mouse embryo","volume":"115","author":"Orr\u2010Urtreger A.","year":"1992","journal-title":"Development"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3175624"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90733-6"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90223-L"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1242\/dev.115.1.123","article-title":"Regulation and role of PDGF receptor a\u2010subunit expression during embyogenesis","volume":"115","author":"Schatteman G. 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