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On one of days 9\u201012 of gestation, groups of TO mice were injected intraperitoneally (IP) with a single dose of 200 mg\/kg of aspirin, or a proportionate volume of physiological saline. An hour later, half of the aspirin\u2010treated animals received a single dose of 0. 03 ml\/g of freshly prepared 25% (v\/v) solution of absolute alcohol and the other half received a proportionate volume of saline. Half of the saline\u2010treated animals received a single dose of 0.3 ml\/g of saline or a proportionate volume of alcohol solution. All animals were killed on day 18 of gestation. Alcohol significantly increased embryonic resorption and caused remarkable intrauterine growth retardation (IUGR). It also induced arched palate, cleft palate and deformities of the digits with haematomas in a modest number of embryos. Aspirin alone did not have teratogenic effects. Pretreatment with aspirin significantly augmented alcohol\u2010induced resorption, IUGR, cleft palate and digital malformations associated with haematomas. Chronological observations on the development of the treated limbs showed the occurrence of vascular stasis, haematomas, edema and cell death at early stages. Subsequently, digital rays were either destroyed (ectrodactyly) or remained hypoplastic (brachydactyly). It appears that limb development in the aspirin\u2010 and alcohol\u2010treated TO mouse embryos is largely affected by vascular disruption. These data provide further evidence to our earlier observation that alcohol and aspirin interact in the production of malformations and that the teratogenic effects of alcohol in the TO mouse are possibly not mediated via treatment related prostaglandin elevation. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/tera.1420510606","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T16:09:25Z","timestamp":1118506165000},"page":"404-417","source":"Crossref","is-referenced-by-count":12,"title":["Aspirin\u2013alcohol interaction in the production of cleft palate and limb malformations in the TO mouse"],"prefix":"10.1002","volume":"51","author":[{"given":"R.","family":"Padmanabhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Pallot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Fetal Alcohol Syndrome","author":"Abel E. 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